Longitudinal association between medication adherence and lung health in people with cystic fibrosis

Michelle N. Eakin; Andrew Bilderback; Michael P. Boyle; Peter J. Mogayzel; Kristin A. Riekert

doi:10.1016/j.jcf.2011.03.005

Longitudinal association between medication adherence and lung health in people with cystic fibrosis

Michelle N. Eakin, Andrew Bilderback, Michael P. Boyle, Peter J. Mogayzel, Kristin A. Riekert

School of Medicine

Research output: Contribution to journal › Article › peer-review

134 Scopus citations

Abstract

Background: This study examined the relationship of medication adherence to frequency of pulmonary exacerbation and rate of decline in FEV₁% predicted (FEV₁). Methods: 95 CF patients aged 6years or older and prescribed a pulmonary medication, were enrolled in a longitudinal retrospective review of medication adherence and health outcomes (the occurrence and frequency of intravenous (IV) antibiotic treatments and FEV₁) over 12-months. Pharmacy refill records were used to calculate a medication possession ratio (MPR). Results: Composite MPR predicted the occurrence of at least one pulmonary exacerbation requiring a course of IV antibiotics (IRR=2.34, p=0.05), but not the frequency of exacerbations, after controlling for gender, baseline FEV_1, and regimen complexity. Composite MPR predicted baseline FEV₁ (estimate=29.81, p=007), but not decline in FEV₁. Conclusions: These results demonstrate a significant relation between medication adherence and IV antibiotics in CF patients, highlighting the importance of addressing adherence during clinic visits to improve health outcomes.

Original language	English (US)
Pages (from-to)	258-264
Number of pages	7
Journal	Journal of Cystic Fibrosis
Volume	10
Issue number	4
DOIs	https://doi.org/10.1016/j.jcf.2011.03.005
State	Published - Jul 2011

Keywords

Adherence
Cystic fibrosis
Health outcomes
Pulmonary exacerbation
Treatment

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pulmonary and Respiratory Medicine

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10.1016/j.jcf.2011.03.005

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title = "Longitudinal association between medication adherence and lung health in people with cystic fibrosis",

abstract = "Background: This study examined the relationship of medication adherence to frequency of pulmonary exacerbation and rate of decline in FEV1% predicted (FEV1). Methods: 95 CF patients aged 6years or older and prescribed a pulmonary medication, were enrolled in a longitudinal retrospective review of medication adherence and health outcomes (the occurrence and frequency of intravenous (IV) antibiotic treatments and FEV1) over 12-months. Pharmacy refill records were used to calculate a medication possession ratio (MPR). Results: Composite MPR predicted the occurrence of at least one pulmonary exacerbation requiring a course of IV antibiotics (IRR=2.34, p=0.05), but not the frequency of exacerbations, after controlling for gender, baseline FEV1, and regimen complexity. Composite MPR predicted baseline FEV1 (estimate=29.81, p=007), but not decline in FEV1. Conclusions: These results demonstrate a significant relation between medication adherence and IV antibiotics in CF patients, highlighting the importance of addressing adherence during clinic visits to improve health outcomes.",

keywords = "Adherence, Cystic fibrosis, Health outcomes, Pulmonary exacerbation, Treatment",

author = "Eakin, {Michelle N.} and Andrew Bilderback and Boyle, {Michael P.} and Mogayzel, {Peter J.} and Riekert, {Kristin A.}",

note = "Funding Information: Funding sources: NHLBI Grants R01 HL087997 and K23 HL075344. ",

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doi = "10.1016/j.jcf.2011.03.005",

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AU - Eakin, Michelle N.

AU - Bilderback, Andrew

AU - Boyle, Michael P.

AU - Mogayzel, Peter J.

AU - Riekert, Kristin A.

N1 - Funding Information: Funding sources: NHLBI Grants R01 HL087997 and K23 HL075344.

PY - 2011/7

Y1 - 2011/7

N2 - Background: This study examined the relationship of medication adherence to frequency of pulmonary exacerbation and rate of decline in FEV1% predicted (FEV1). Methods: 95 CF patients aged 6years or older and prescribed a pulmonary medication, were enrolled in a longitudinal retrospective review of medication adherence and health outcomes (the occurrence and frequency of intravenous (IV) antibiotic treatments and FEV1) over 12-months. Pharmacy refill records were used to calculate a medication possession ratio (MPR). Results: Composite MPR predicted the occurrence of at least one pulmonary exacerbation requiring a course of IV antibiotics (IRR=2.34, p=0.05), but not the frequency of exacerbations, after controlling for gender, baseline FEV1, and regimen complexity. Composite MPR predicted baseline FEV1 (estimate=29.81, p=007), but not decline in FEV1. Conclusions: These results demonstrate a significant relation between medication adherence and IV antibiotics in CF patients, highlighting the importance of addressing adherence during clinic visits to improve health outcomes.

AB - Background: This study examined the relationship of medication adherence to frequency of pulmonary exacerbation and rate of decline in FEV1% predicted (FEV1). Methods: 95 CF patients aged 6years or older and prescribed a pulmonary medication, were enrolled in a longitudinal retrospective review of medication adherence and health outcomes (the occurrence and frequency of intravenous (IV) antibiotic treatments and FEV1) over 12-months. Pharmacy refill records were used to calculate a medication possession ratio (MPR). Results: Composite MPR predicted the occurrence of at least one pulmonary exacerbation requiring a course of IV antibiotics (IRR=2.34, p=0.05), but not the frequency of exacerbations, after controlling for gender, baseline FEV1, and regimen complexity. Composite MPR predicted baseline FEV1 (estimate=29.81, p=007), but not decline in FEV1. Conclusions: These results demonstrate a significant relation between medication adherence and IV antibiotics in CF patients, highlighting the importance of addressing adherence during clinic visits to improve health outcomes.

KW - Adherence

KW - Cystic fibrosis

KW - Health outcomes

KW - Pulmonary exacerbation

KW - Treatment

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Longitudinal association between medication adherence and lung health in people with cystic fibrosis

Abstract

Keywords

ASJC Scopus subject areas

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