Long-term stability of serum sodium in hemodialysis patients

Aldo J. Peixoto, Nayan Gowda, Chirag R. Parikh, Sergio F.F. Santos

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Background: A direct relationship between dialysate-to-plasma sodium gradient, blood pressure and interdialytic weight gain exists in hemodialysis (HD) patients. The aim of this study was to delineate the long-term variability of serum sodium in HD patients. Methods: We performed a retrospective cohort analysis of serum sodium and other analytes routinely evaluated in 100 stable chronic HD patients observed for 12 months. Results: Individual levels across the cohort varied from 122 to 145 mM, but 12-month intraindividual coefficients of variation for sodium were low (pre-HD = 1.6%; post-HD = 1.8%) with overall variability similar to that related to laboratory assay variability especially when compared with other analytes (3.1-30.8%). Pre-HD serum sodium had a trend toward hyponatremia (mean 136 ± 0.8 mM). Conclusion: Serum sodium is stable over time in HD patients. Pre-HD serum sodium may be used as a parameter for individualizing dialysate sodium prescription.

Original languageEnglish (US)
Pages (from-to)264-267
Number of pages4
JournalBlood Purification
Issue number3
StatePublished - Mar 2010
Externally publishedYes


  • Dialysate sodium
  • Hemodialysis
  • Serum sodium

ASJC Scopus subject areas

  • Hematology
  • Nephrology


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