TY - JOUR
T1 - Long-term, home-based transcranial direct current stimulation coupled with computerized cognitive training in frontotemporal dementia
T2 - A case report
AU - Tippett, Donna C.
AU - Neophytou, Kyriaki
AU - Tao, Yuan
AU - Gallegos, Jessica
AU - Morrow, Christopher
AU - Onyike, Chiadi U.
AU - Tsapkini, Kyrana
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - We present the case of a 62-year-old woman with probable behavioral variant of frontotemporal dementia (bvFTD) with cognitive/language deficits who demonstrated improved performance on cognitive/language testing and in functional tasks following long-term, home-based transcranial direct current stimulation (tDCS) coupled with computerized cognitive training (CCT). The patient underwent home-based tDCS (anode on the left prefrontal cortex and cathode on the right homologue) for 46 sessions over 10 weeks along with CCT. On post-treatment testing, the patient improved by 3 points on the Mini-Mental State Exam (MMSE) (23 to 26). She also showed improvement on several cognitive/language tasks, such as immediate recall of single words and word pairs, total accurate words in sentence repetition, delayed recall, semantic processing, and sentence level comprehension. There was no decline in several other cognitive and language tasks. Family members reported subjective improvements in expressiveness, communication, and interaction with others as well as increased attention to grooming and style which contrasted with her pre-treatment condition. This report suggests that home-based tDCS combined with CCT for an extended period may slow decline, and improve cognitive/language performance and everyday function in FTD.
AB - We present the case of a 62-year-old woman with probable behavioral variant of frontotemporal dementia (bvFTD) with cognitive/language deficits who demonstrated improved performance on cognitive/language testing and in functional tasks following long-term, home-based transcranial direct current stimulation (tDCS) coupled with computerized cognitive training (CCT). The patient underwent home-based tDCS (anode on the left prefrontal cortex and cathode on the right homologue) for 46 sessions over 10 weeks along with CCT. On post-treatment testing, the patient improved by 3 points on the Mini-Mental State Exam (MMSE) (23 to 26). She also showed improvement on several cognitive/language tasks, such as immediate recall of single words and word pairs, total accurate words in sentence repetition, delayed recall, semantic processing, and sentence level comprehension. There was no decline in several other cognitive and language tasks. Family members reported subjective improvements in expressiveness, communication, and interaction with others as well as increased attention to grooming and style which contrasted with her pre-treatment condition. This report suggests that home-based tDCS combined with CCT for an extended period may slow decline, and improve cognitive/language performance and everyday function in FTD.
KW - Frontotemporal dementia
KW - behavioral variant frontotemporal dementia
KW - case report
KW - transcranial direct current stimulation
UR - http://www.scopus.com/inward/record.url?scp=85195122526&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85195122526&partnerID=8YFLogxK
U2 - 10.1177/11795735241258435
DO - 10.1177/11795735241258435
M3 - Article
C2 - 38835997
AN - SCOPUS:85195122526
SN - 1179-5735
VL - 16
JO - Journal of Central Nervous System Disease
JF - Journal of Central Nervous System Disease
ER -