Long-term effects of repeated methylamphetamine administration on dopamine and serotonin neurons in the rat brain: A regional study

George A. Ricaurte; Charles R. Schuster; Lewis S. Seiden

doi:10.1016/0006-8993(80)90952-X

Long-term effects of repeated methylamphetamine administration on dopamine and serotonin neurons in the rat brain: A regional study

George A. Ricaurte, Charles R. Schuster, Lewis S. Seiden

Research output: Contribution to journal › Article › peer-review

438 Scopus citations

Abstract

Repeated high doses (25 and 100 mg/kg) of methylamphetamine produce long-term depletions of both dopamine (DA) and serotonin (5-HT) in the rat brain. In the DA system, depletions are most pronounced in the neostriatum and substantia nigra, with decreased levels in these two regions being significantly correlated. Within the 5-HT system, levels are most reduced in the amygdala, frontal cortex and neostriatum. When both the DA and 5-HT depleting actions of methylamphetamine are considered, the hypothalamus stands out as one of the more resistant brain regions. The regional pattern of reduced 5-HT levels following methylamphetamine is similar to that seen after p-chloroamphetamine. After both methylamphetamine and p-chloroamphetamine, a loss of 5-HT synaptosomal uptake sites occurs. Serotonergic systems are more sensitive than DA systems to the apparent neurotoxic actions of methylamphetamine.

Original language	English (US)
Pages (from-to)	153-163
Number of pages	11
Journal	Brain research
Volume	193
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(80)90952-X
State	Published - Jul 7 1980
Externally published	Yes

Keywords

dopamine
methylamphetamine
neurotoxicity
serotonin

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(80)90952-X

Cite this

@article{3c116aeeba904627baf2dcdcd6059fcb,

title = "Long-term effects of repeated methylamphetamine administration on dopamine and serotonin neurons in the rat brain: A regional study",

abstract = "Repeated high doses (25 and 100 mg/kg) of methylamphetamine produce long-term depletions of both dopamine (DA) and serotonin (5-HT) in the rat brain. In the DA system, depletions are most pronounced in the neostriatum and substantia nigra, with decreased levels in these two regions being significantly correlated. Within the 5-HT system, levels are most reduced in the amygdala, frontal cortex and neostriatum. When both the DA and 5-HT depleting actions of methylamphetamine are considered, the hypothalamus stands out as one of the more resistant brain regions. The regional pattern of reduced 5-HT levels following methylamphetamine is similar to that seen after p-chloroamphetamine. After both methylamphetamine and p-chloroamphetamine, a loss of 5-HT synaptosomal uptake sites occurs. Serotonergic systems are more sensitive than DA systems to the apparent neurotoxic actions of methylamphetamine.",

keywords = "dopamine, methylamphetamine, neurotoxicity, serotonin",

author = "Ricaurte, {George A.} and Schuster, {Charles R.} and Seiden, {Lewis S.}",

note = "Funding Information: We thank E. B. Welch for help with the preparation of the manuscript. G. A. Ricaurte was supported by the Insurance Medical Scientist Scholarship Fund (Home Life Insurance Company, New York). L. Seiden is supported by a Research Scientist Award MH-10562. This study was supported in part by USPH NIDA Grants DA 00250 and DA 00085.",

year = "1980",

month = jul,

day = "7",

doi = "10.1016/0006-8993(80)90952-X",

language = "English (US)",

volume = "193",

pages = "153--163",

journal = "Brain research",

issn = "0006-8993",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Long-term effects of repeated methylamphetamine administration on dopamine and serotonin neurons in the rat brain

T2 - A regional study

AU - Ricaurte, George A.

AU - Schuster, Charles R.

AU - Seiden, Lewis S.

N1 - Funding Information: We thank E. B. Welch for help with the preparation of the manuscript. G. A. Ricaurte was supported by the Insurance Medical Scientist Scholarship Fund (Home Life Insurance Company, New York). L. Seiden is supported by a Research Scientist Award MH-10562. This study was supported in part by USPH NIDA Grants DA 00250 and DA 00085.

PY - 1980/7/7

Y1 - 1980/7/7

N2 - Repeated high doses (25 and 100 mg/kg) of methylamphetamine produce long-term depletions of both dopamine (DA) and serotonin (5-HT) in the rat brain. In the DA system, depletions are most pronounced in the neostriatum and substantia nigra, with decreased levels in these two regions being significantly correlated. Within the 5-HT system, levels are most reduced in the amygdala, frontal cortex and neostriatum. When both the DA and 5-HT depleting actions of methylamphetamine are considered, the hypothalamus stands out as one of the more resistant brain regions. The regional pattern of reduced 5-HT levels following methylamphetamine is similar to that seen after p-chloroamphetamine. After both methylamphetamine and p-chloroamphetamine, a loss of 5-HT synaptosomal uptake sites occurs. Serotonergic systems are more sensitive than DA systems to the apparent neurotoxic actions of methylamphetamine.

AB - Repeated high doses (25 and 100 mg/kg) of methylamphetamine produce long-term depletions of both dopamine (DA) and serotonin (5-HT) in the rat brain. In the DA system, depletions are most pronounced in the neostriatum and substantia nigra, with decreased levels in these two regions being significantly correlated. Within the 5-HT system, levels are most reduced in the amygdala, frontal cortex and neostriatum. When both the DA and 5-HT depleting actions of methylamphetamine are considered, the hypothalamus stands out as one of the more resistant brain regions. The regional pattern of reduced 5-HT levels following methylamphetamine is similar to that seen after p-chloroamphetamine. After both methylamphetamine and p-chloroamphetamine, a loss of 5-HT synaptosomal uptake sites occurs. Serotonergic systems are more sensitive than DA systems to the apparent neurotoxic actions of methylamphetamine.

KW - dopamine

KW - methylamphetamine

KW - neurotoxicity

KW - serotonin

UR - http://www.scopus.com/inward/record.url?scp=0018824851&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018824851&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(80)90952-X

DO - 10.1016/0006-8993(80)90952-X

M3 - Article

C2 - 7378814

AN - SCOPUS:0018824851

SN - 0006-8993

VL - 193

SP - 153

EP - 163

JO - Brain research

JF - Brain research

IS - 1

ER -

Long-term effects of repeated methylamphetamine administration on dopamine and serotonin neurons in the rat brain: A regional study

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this