Long-term effects of chronic methamphetamine administration in rhesus monkeys

William L. Woolverton; George A. Ricaurte; Lysia S. Forno; Lewis S. Seiden

doi:10.1016/0006-8993(89)91279-1

Long-term effects of chronic methamphetamine administration in rhesus monkeys

William L. Woolverton, George A. Ricaurte, Lysia S. Forno, Lewis S. Seiden

School of Medicine

Research output: Contribution to journal › Article › peer-review

170 Scopus citations

Abstract

Biochemical and neuropathological effects of exposure to a high dose regimen of methamphetamine were evaluated in rhesus monkeys approximately 4 years after the last drug injection. Concentrations of dopamine and serotonin in caudate were below control levels as were concentrations of serotonin in several other brain regions. These changes were more severe in a monkey that was exposed twice to the drug regimen. A decrease in caudate synaptosomal uptake of both neurotransmitters as well as neuropathological changes were evident in that monkey. Although it is possible that partial recovery occurred, these results strongly suggest that methamphetamine-induced neurotoxicity may be permanent.

Original language	English (US)
Pages (from-to)	73-78
Number of pages	6
Journal	Brain research
Volume	486
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(89)91279-1
State	Published - May 1 1989

Keywords

Brain
Dopamine
Methamphetamine
Neurotoxicity
Rhesus monkey
Serotonin

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(89)91279-1

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title = "Long-term effects of chronic methamphetamine administration in rhesus monkeys",

abstract = "Biochemical and neuropathological effects of exposure to a high dose regimen of methamphetamine were evaluated in rhesus monkeys approximately 4 years after the last drug injection. Concentrations of dopamine and serotonin in caudate were below control levels as were concentrations of serotonin in several other brain regions. These changes were more severe in a monkey that was exposed twice to the drug regimen. A decrease in caudate synaptosomal uptake of both neurotransmitters as well as neuropathological changes were evident in that monkey. Although it is possible that partial recovery occurred, these results strongly suggest that methamphetamine-induced neurotoxicity may be permanent.",

keywords = "Brain, Dopamine, Methamphetamine, Neurotoxicity, Rhesus monkey, Serotonin",

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T1 - Long-term effects of chronic methamphetamine administration in rhesus monkeys

AU - Woolverton, William L.

AU - Ricaurte, George A.

AU - Forno, Lysia S.

AU - Seiden, Lewis S.

PY - 1989/5/1

Y1 - 1989/5/1

N2 - Biochemical and neuropathological effects of exposure to a high dose regimen of methamphetamine were evaluated in rhesus monkeys approximately 4 years after the last drug injection. Concentrations of dopamine and serotonin in caudate were below control levels as were concentrations of serotonin in several other brain regions. These changes were more severe in a monkey that was exposed twice to the drug regimen. A decrease in caudate synaptosomal uptake of both neurotransmitters as well as neuropathological changes were evident in that monkey. Although it is possible that partial recovery occurred, these results strongly suggest that methamphetamine-induced neurotoxicity may be permanent.

AB - Biochemical and neuropathological effects of exposure to a high dose regimen of methamphetamine were evaluated in rhesus monkeys approximately 4 years after the last drug injection. Concentrations of dopamine and serotonin in caudate were below control levels as were concentrations of serotonin in several other brain regions. These changes were more severe in a monkey that was exposed twice to the drug regimen. A decrease in caudate synaptosomal uptake of both neurotransmitters as well as neuropathological changes were evident in that monkey. Although it is possible that partial recovery occurred, these results strongly suggest that methamphetamine-induced neurotoxicity may be permanent.

KW - Brain

KW - Dopamine

KW - Methamphetamine

KW - Neurotoxicity

KW - Rhesus monkey

KW - Serotonin

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Long-term effects of chronic methamphetamine administration in rhesus monkeys

Abstract

Keywords

ASJC Scopus subject areas

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