Long-term benefits of aggressive treatment for primary colorectal cancer

Peter Klein, David Allison, Sadik Khuder, Arlene Walsh, Zeenat Khan, Daniel Smith, Thomas Webb

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The long-term follow up of 128 colorectal cancer patients is reported. Seventy-nine percent (101/128) of the patients had curative resections: 70 patients had radical lymphadenectomies with wide removal of tumor-adjacent nodes, and 31 patients had standard resections. The 5-year overall survival rates for Dukes' stage B and C patients and for all rectosigmoid cancer patients significantly favored radical resection (60% vs. 38%, 57% vs. 29%, respectively, P < 0.05). Tumor-free survival rates were also higher after radical lymphadenectomy but did not reach statistical significance. Eleven percent (14/128) of the patients required multiorgan resections, and/or preoperative radiation to render fixed cancers resectable, and these patients had a 10-year tumor-free survival rate of 45%, compared to zero % 5-year survival for the 27 patients who underwent palliative procedures (P < 0.01). These results confirm that many colorectal cancer patients will be cured with aggressive treatment and they support the need for a controlled trial for evaluation of lymphadenectomy for this disease.

Original languageEnglish (US)
Pages (from-to)258-266
Number of pages9
JournalJournal of Surgical Oncology
Issue number4
StatePublished - Aug 1996
Externally publishedYes


  • colorectal cancer
  • lymphadenectomy
  • radical surgery

ASJC Scopus subject areas

  • Surgery
  • Oncology


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