TY - JOUR
T1 - Long-term assessment of inflammation and healthy aging in late life
T2 - The cardiovascular health study all stars
AU - Jenny, Nancy S.
AU - French, Benjamin
AU - Arnold, Alice M.
AU - Strotmeyer, Elsa S.
AU - Cushman, Mary
AU - Chaves, Paulo H.M.
AU - Ding, Jingzhong
AU - Fried, Linda P.
AU - Kritchevsky, Stephen B.
AU - Rifkin, Dena E.
AU - Sarnak, Mark J.
AU - Newman, Anne B.
N1 - Funding Information:
The research reported in this article was supported by the National Institute on Aging (R01-AG-023629). The CHS was supported by contracts N01-HC-85239 , N01-HC-85079 through N01-HC-85086 , N01-HC-35129 , N01 HC-15103 , N01 HC-55222 , N01-HC-75150 , N01-HC-45133 , and grant HL080295 from the National Heart, Lung, and Blood Institute , with additional contribution from the National Institute of Neurological Disorders and Stroke . Additional support was provided through AG-15928, AG-20098, AG-027002, and AG-027058 from the National Institute on Aging . A full list of principal CHS investigators and institutions can be found at http //www.chs-nhlbi.org / pi . htm .
PY - 2012/9
Y1 - 2012/9
N2 - Background.Associations of inflammation with age-related pathologies are documented; however, it is not understood how changes in inflammation over time impact healthy aging. Methods.We examined associations of long-term change in C-reactive protein (CRP) and interleukin-6 (IL-6) with concurrent onset of physical and cognitive impairment, subsequent cardiovascular disease (CVD), and mortality in 1,051 participants in the Cardiovascular Health Study All Stars Study. Biomarkers were measured in 1996-1997 and 2005-2006. Results. In 2005-2006, median age was 84.9 years, 63% were women and 17% non-white; 21% had at least a doubling in CRP over time and 23% had at least a doubling in IL-6. Adjusting for demographics, CVD risk factors, and 1996-1997 CRP level, each doubling in CRP change over 9 years was associated with higher risk of physical or cognitive impairment (odds ratio 1.29; 95% confidence interval 1.15, 1.45). Results were similar for IL-6 (1.45; 1.20, 1.76). A doubling in IL-6 change over time, but not CRP, was associated with incident CVD events; hazard ratio (95% confidence interval) 1.34 (1.03, 1.75). Doubling in change in each biomarker was individually associated with mortality (CRP: 1.12 [1.03, 1.22]; IL-6 1.39 [1.16, 1.65]). In models containing both change and 2005-2006 level, only level was associated with CVD events and mortality. Conclusions .Although increases in inflammation markers over 9 years were associated with higher concurrent risk of functional impairment and subsequent CVD events and mortality, final levels of each biomarker appeared to be more important in determining risk of subsequent events than change over time
AB - Background.Associations of inflammation with age-related pathologies are documented; however, it is not understood how changes in inflammation over time impact healthy aging. Methods.We examined associations of long-term change in C-reactive protein (CRP) and interleukin-6 (IL-6) with concurrent onset of physical and cognitive impairment, subsequent cardiovascular disease (CVD), and mortality in 1,051 participants in the Cardiovascular Health Study All Stars Study. Biomarkers were measured in 1996-1997 and 2005-2006. Results. In 2005-2006, median age was 84.9 years, 63% were women and 17% non-white; 21% had at least a doubling in CRP over time and 23% had at least a doubling in IL-6. Adjusting for demographics, CVD risk factors, and 1996-1997 CRP level, each doubling in CRP change over 9 years was associated with higher risk of physical or cognitive impairment (odds ratio 1.29; 95% confidence interval 1.15, 1.45). Results were similar for IL-6 (1.45; 1.20, 1.76). A doubling in IL-6 change over time, but not CRP, was associated with incident CVD events; hazard ratio (95% confidence interval) 1.34 (1.03, 1.75). Doubling in change in each biomarker was individually associated with mortality (CRP: 1.12 [1.03, 1.22]; IL-6 1.39 [1.16, 1.65]). In models containing both change and 2005-2006 level, only level was associated with CVD events and mortality. Conclusions .Although increases in inflammation markers over 9 years were associated with higher concurrent risk of functional impairment and subsequent CVD events and mortality, final levels of each biomarker appeared to be more important in determining risk of subsequent events than change over time
KW - Aging
KW - Cognitive function
KW - Inflammation
KW - Physical function
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U2 - 10.1093/gerona/glr261
DO - 10.1093/gerona/glr261
M3 - Article
C2 - 22367431
AN - SCOPUS:84865788293
SN - 1079-5006
VL - 67 A
SP - 970
EP - 976
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 9
ER -