TY - JOUR
T1 - Long-term (96-week) Efficacy and Safety After Switching from Tenofovir Disoproxil Fumarate (TDF) to Tenofovir Alafenamide (TAF) in HIV-infected, Virologically Suppressed Adults
AU - Raffi, Francois
AU - Orkin, Chloe
AU - Clarke, Amanda
AU - Slama, Laurence
AU - Gallant, Joel
AU - Daar, Eric
AU - Henry, Keith
AU - Santana-Bagur, Jorge
AU - Stein, David K.
AU - Bellos, Nicholaos
AU - Scarsella, Anthony
AU - Yan, Mingjin
AU - Abram, Michael E.
AU - Cheng, Andrew
AU - Rhee, Martin S S
PY - 2017/3/6
Y1 - 2017/3/6
N2 - ABSTRACT:: In a double-blind, phase 3 trial, 663 HIV-infected, virologically suppressed adults were randomized to switch to tenofovir alafenamide (TAF; n=333) vs. remain on tenofovir disoproxil fumarate (TDF; n=330), each coformulated with emtricitabine (FTC), while continuing their third agent (boosted protease inhibitor or unboosted third agent). At week 96, 88.6% on FTC/TAF and 89.1% on FTC/TDF had HIV-1 RNA <50 copies/mL (adjusted difference -0.5%; 95%CI [-5.3%, 4.4%]). Proteinuria, albuminuria, proximal renal tubular function, and bone mineral density improved after switching to TAF- from TDF-containing regimens. These longer-term data support FTC/TAF as a safe, well tolerated, and durable nucleotide reverse transcriptase inhibitor backbone.
AB - ABSTRACT:: In a double-blind, phase 3 trial, 663 HIV-infected, virologically suppressed adults were randomized to switch to tenofovir alafenamide (TAF; n=333) vs. remain on tenofovir disoproxil fumarate (TDF; n=330), each coformulated with emtricitabine (FTC), while continuing their third agent (boosted protease inhibitor or unboosted third agent). At week 96, 88.6% on FTC/TAF and 89.1% on FTC/TDF had HIV-1 RNA <50 copies/mL (adjusted difference -0.5%; 95%CI [-5.3%, 4.4%]). Proteinuria, albuminuria, proximal renal tubular function, and bone mineral density improved after switching to TAF- from TDF-containing regimens. These longer-term data support FTC/TAF as a safe, well tolerated, and durable nucleotide reverse transcriptase inhibitor backbone.
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U2 - 10.1097/QAI.0000000000001344
DO - 10.1097/QAI.0000000000001344
M3 - Article
C2 - 28272164
AN - SCOPUS:85014657477
SN - 1525-4135
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
ER -