Long-lasting, specific immunologic unresponsiveness associated with cryptococcal meningitis

D. K. Henderson, J. E. Bennett, M. A. Huber

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


A sensitive radioimmunoassay and an antibody class-specific enzyme-linked immunosorbent assay were used to determine whether patients cured of cryptococcosis responded normally to immunization with cryptococcal capsular polysaccharide (CPS) and type III pneumococcal polysaccharide. 10 normal volunteers and 8 patients who had been cured of cryptococcal meningitis and who had no serious underlying diseases were immunized with both antigens. Geometric mean titers to CPS measured by radioimmunoassay were 1:1 in both groups before vaccination, but were 1:3 in patients and 1:119 in controls following immunization (P<0.01, Student's t test). Analysis of the class-specific response to immunization with CPS found little anti-CPS IgG or IgA. Geometric mean postvaccination IgM titers were 1:31 in patients and 1:238 in controls (P<0.01). Responses to immunization with type III pneumococcal polysaccharide were similar in patients and controls, with IgA, IgM, and IgG mean titers of 1:1129, 1:369, and 1:158 in patients and 1:1504, 1:1039, and 1:163 in controls (P<0.2 for each antibody class).

Original languageEnglish (US)
Pages (from-to)1185-1190
Number of pages6
JournalJournal of Clinical Investigation
Issue number5
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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