LONG-LASTING DYSKINESIA INDUCED BY LEVODOPA

James L. Weiss; Larry K.Y. Ng; Thomas N. Chase

doi:10.1016/S0140-6736(71)91410-3

LONG-LASTING DYSKINESIA INDUCED BY LEVODOPA

James L. Weiss, Larry K.Y. Ng, Thomas N. Chase

Research output: Contribution to journal › Letter › peer-review

Original language	English (US)
Pages (from-to)	1016-1017
Number of pages	2
Journal	The Lancet
Volume	297
Issue number	7707
DOIs	https://doi.org/10.1016/S0140-6736(71)91410-3
State	Published - May 15 1971
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1016/S0140-6736(71)91410-3

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@article{6f7dc54331214c2fa438a923e1bf2da7,

title = "LONG-LASTING DYSKINESIA INDUCED BY LEVODOPA",

author = "Weiss, {James L.} and Ng, {Larry K.Y.} and Chase, {Thomas N.}",

note = "Funding Information: From March to October, 1970-a period similar to the time of apparent clustering reported by Kardon et awl. 2 and Shapiro 3-3 cases of trisomy 18 were observed in 1570 births. This incidence of 1/500 births for our series is in close agreement with the 1/600 and 1/774 reported by these other workers. However, even more striking is the cluster- ing of cases in 1968 (7/3137 or 1/450 births), a 10-fold increase over the population frequency. There was no apparent ethnic, racial, or geographical concentration of the cases within the area served by Children{\textquoteright}s Hospital of Buffalo. letiological or epidemiological reasons for this distribution are difficult to propose. The mean maternal age at the birth of the propositi of this study was 31-2, which compares well with the estimate of 31-5 years for trisomy-18 cases in the general population. Although from 1966 to 1970 the ages of the mothers of the affected children varied considerably (20-43), during the period in question, all 3 mothers were below 30, which is in agreement with the younger maternal ages observed in the other clusters. 2,3 The sex ratio among the index cases in this series was 0-5, which is in keeping with the observation of a predilection for females. 4 Among the 15 cases observed, 1 demonstrated double aneuploidy (trisomy 18 and XXY),6 1 trisomy 18/normal mosaicism, and 1 was a heterozygous carrier for a sporadic 18/21 translocation. Now that three independent investi- gations have suggested temporal clustering of the trisomy- 18 syndrome, it would be of interest to learn whether other investigators have observed a similar phenomenon. This work was supported by a grant from the U.S. Children{\textquoteright}s Bureau (project no. 417). Division of Human Genetics, Department of Pediatrics, State University of New York at Buffalo School of Medicine and Children{\textquoteright}s Hospital of Buffalo, Buffalo, N.Y. 14222.",

year = "1971",

month = may,

day = "15",

doi = "10.1016/S0140-6736(71)91410-3",

language = "English (US)",

volume = "297",

pages = "1016--1017",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier Limited",

number = "7707",

}

TY - JOUR

T1 - LONG-LASTING DYSKINESIA INDUCED BY LEVODOPA

AU - Weiss, James L.

AU - Ng, Larry K.Y.

AU - Chase, Thomas N.

N1 - Funding Information: From March to October, 1970-a period similar to the time of apparent clustering reported by Kardon et awl. 2 and Shapiro 3-3 cases of trisomy 18 were observed in 1570 births. This incidence of 1/500 births for our series is in close agreement with the 1/600 and 1/774 reported by these other workers. However, even more striking is the cluster- ing of cases in 1968 (7/3137 or 1/450 births), a 10-fold increase over the population frequency. There was no apparent ethnic, racial, or geographical concentration of the cases within the area served by Children’s Hospital of Buffalo. letiological or epidemiological reasons for this distribution are difficult to propose. The mean maternal age at the birth of the propositi of this study was 31-2, which compares well with the estimate of 31-5 years for trisomy-18 cases in the general population. Although from 1966 to 1970 the ages of the mothers of the affected children varied considerably (20-43), during the period in question, all 3 mothers were below 30, which is in agreement with the younger maternal ages observed in the other clusters. 2,3 The sex ratio among the index cases in this series was 0-5, which is in keeping with the observation of a predilection for females. 4 Among the 15 cases observed, 1 demonstrated double aneuploidy (trisomy 18 and XXY),6 1 trisomy 18/normal mosaicism, and 1 was a heterozygous carrier for a sporadic 18/21 translocation. Now that three independent investi- gations have suggested temporal clustering of the trisomy- 18 syndrome, it would be of interest to learn whether other investigators have observed a similar phenomenon. This work was supported by a grant from the U.S. Children’s Bureau (project no. 417). Division of Human Genetics, Department of Pediatrics, State University of New York at Buffalo School of Medicine and Children’s Hospital of Buffalo, Buffalo, N.Y. 14222.

PY - 1971/5/15

Y1 - 1971/5/15

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U2 - 10.1016/S0140-6736(71)91410-3

DO - 10.1016/S0140-6736(71)91410-3

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AN - SCOPUS:0015225611

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SP - 1016

EP - 1017

JO - The Lancet

JF - The Lancet

IS - 7707

ER -

LONG-LASTING DYSKINESIA INDUCED BY LEVODOPA

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