Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12→q13

C. E. Carow; E. Kim; A. L. Hawkins; H. D. Webb; C. A. Griffin; E. W. Jabs; C. I. Civin; Donald Small

doi:10.1159/000134046

Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12→q13

C. E. Carow, E. Kim, A. L. Hawkins, H. D. Webb, C. A. Griffin, E. W. Jabs, C. I. Civin, Donald Small

School of Medicine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

We have previously reported the cloning of stem cell tyrosine kinase-1 (STK-1, gene symbol FLT3), the human homolog of the mouse Flk2/Flt3 gene (Small et al., 1994). This growth factor receptor is expressed in CD34⁺ human bone marrow (stem/progenitor) cells. We have mapped the gene for STK-1 using PCR screening of a human-rodent somatic cell hybrid panel, and fluorescence in situ molecular hybridization (FISH) of STK-1 genomic probes to mitotic chromosomes of normal human lymphocytes. The results of both analyses show that the gene for STK-1 (FLT3) localizes to chromosome 13q12→q13.

Original language	English (US)
Pages (from-to)	255-257
Number of pages	3
Journal	Cytogenetics and cell genetics
Volume	70
Issue number	3-4
DOIs	https://doi.org/10.1159/000134046
State	Published - 1995

ASJC Scopus subject areas

Genetics
Cell Biology

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title = "Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12→q13",

abstract = "We have previously reported the cloning of stem cell tyrosine kinase-1 (STK-1, gene symbol FLT3), the human homolog of the mouse Flk2/Flt3 gene (Small et al., 1994). This growth factor receptor is expressed in CD34+ human bone marrow (stem/progenitor) cells. We have mapped the gene for STK-1 using PCR screening of a human-rodent somatic cell hybrid panel, and fluorescence in situ molecular hybridization (FISH) of STK-1 genomic probes to mitotic chromosomes of normal human lymphocytes. The results of both analyses show that the gene for STK-1 (FLT3) localizes to chromosome 13q12→q13.",

author = "Carow, {C. E.} and E. Kim and Hawkins, {A. L.} and Webb, {H. D.} and Griffin, {C. A.} and Jabs, {E. W.} and Civin, {C. I.} and Donald Small",

year = "1995",

doi = "10.1159/000134046",

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pages = "255--257",

journal = "Cytogenetics and cell genetics",

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T1 - Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12→q13

AU - Carow, C. E.

AU - Kim, E.

AU - Hawkins, A. L.

AU - Webb, H. D.

AU - Griffin, C. A.

AU - Jabs, E. W.

AU - Civin, C. I.

AU - Small, Donald

PY - 1995

Y1 - 1995

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AB - We have previously reported the cloning of stem cell tyrosine kinase-1 (STK-1, gene symbol FLT3), the human homolog of the mouse Flk2/Flt3 gene (Small et al., 1994). This growth factor receptor is expressed in CD34+ human bone marrow (stem/progenitor) cells. We have mapped the gene for STK-1 using PCR screening of a human-rodent somatic cell hybrid panel, and fluorescence in situ molecular hybridization (FISH) of STK-1 genomic probes to mitotic chromosomes of normal human lymphocytes. The results of both analyses show that the gene for STK-1 (FLT3) localizes to chromosome 13q12→q13.

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Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12→q13

Abstract

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