Local drug delivery to the brain

Paul P. Wang; James Frazier; Henry Brem

doi:10.1016/S0169-409X(02)00054-6

Local drug delivery to the brain

Paul P. Wang, James Frazier, Henry Brem

School of Medicine

Research output: Contribution to journal › Article › peer-review

132 Scopus citations

Abstract

The controlled local delivery of antineoplastic agents by biodegradable polymers is a technique that allows for exposure of tumor cells to therapeutic doses of an active agent for prolonged periods of time while avoiding high systemic doses associated with debilitating toxicities. The use of polymers for chemotherapy delivery expands the spectrum of available treatment of neoplasms in the central nervous system, and facilitates new approaches for the treatment of malignant gliomas. In this article, we discuss the rationale and history of the development and use of these polymers, and review the various agents that have used this technology to treat malignant brain tumors.

Original language	English (US)
Pages (from-to)	987-1013
Number of pages	27
Journal	Advanced Drug Delivery Reviews
Volume	54
Issue number	7
DOIs	https://doi.org/10.1016/S0169-409X(02)00054-6
State	Published - Oct 16 2002

Keywords

Astrocytoma
BCNU
Brain tumor
Chemotherapy
Gliadel®
Glioblastoma multiforme
Glioma
Implantable polymer
Local drug delivery

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/S0169-409X(02)00054-6

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title = "Local drug delivery to the brain",

abstract = "The controlled local delivery of antineoplastic agents by biodegradable polymers is a technique that allows for exposure of tumor cells to therapeutic doses of an active agent for prolonged periods of time while avoiding high systemic doses associated with debilitating toxicities. The use of polymers for chemotherapy delivery expands the spectrum of available treatment of neoplasms in the central nervous system, and facilitates new approaches for the treatment of malignant gliomas. In this article, we discuss the rationale and history of the development and use of these polymers, and review the various agents that have used this technology to treat malignant brain tumors.",

keywords = "Astrocytoma, BCNU, Brain tumor, Chemotherapy, Gliadel{\textregistered}, Glioblastoma multiforme, Glioma, Implantable polymer, Local drug delivery",

author = "Wang, {Paul P.} and James Frazier and Henry Brem",

note = "Funding Information: The research presented in this work has been supported in part by the National Cooperative Drug Discovery Group (UO1-CA52857 and AI 47739) of the National Cancer Institute (NCI-NIH), Bethesda, MD. Dr Wang is a neurosurgical fellow whose research is supported by a grant from the National Institute of Health/The Johns Hopkins University, Bethesda/Baltimore, MD. James Frazier is supported by a grant from the Howard Hughes Medical Institute, Bethesda, MD. Dr Brem is a consultant to Guilford Pharmaceuticals, Inc. and to Aventis Pharmaceutical Products, Inc. The Johns Hopkins University and Dr Brem own Guilford stock, the sale of which is subject to restrictions under University policy. The terms of this arrangement are managed by the university with its conflict of interest policies.",

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doi = "10.1016/S0169-409X(02)00054-6",

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AU - Wang, Paul P.

AU - Frazier, James

AU - Brem, Henry

N1 - Funding Information: The research presented in this work has been supported in part by the National Cooperative Drug Discovery Group (UO1-CA52857 and AI 47739) of the National Cancer Institute (NCI-NIH), Bethesda, MD. Dr Wang is a neurosurgical fellow whose research is supported by a grant from the National Institute of Health/The Johns Hopkins University, Bethesda/Baltimore, MD. James Frazier is supported by a grant from the Howard Hughes Medical Institute, Bethesda, MD. Dr Brem is a consultant to Guilford Pharmaceuticals, Inc. and to Aventis Pharmaceutical Products, Inc. The Johns Hopkins University and Dr Brem own Guilford stock, the sale of which is subject to restrictions under University policy. The terms of this arrangement are managed by the university with its conflict of interest policies.

PY - 2002/10/16

Y1 - 2002/10/16

N2 - The controlled local delivery of antineoplastic agents by biodegradable polymers is a technique that allows for exposure of tumor cells to therapeutic doses of an active agent for prolonged periods of time while avoiding high systemic doses associated with debilitating toxicities. The use of polymers for chemotherapy delivery expands the spectrum of available treatment of neoplasms in the central nervous system, and facilitates new approaches for the treatment of malignant gliomas. In this article, we discuss the rationale and history of the development and use of these polymers, and review the various agents that have used this technology to treat malignant brain tumors.

AB - The controlled local delivery of antineoplastic agents by biodegradable polymers is a technique that allows for exposure of tumor cells to therapeutic doses of an active agent for prolonged periods of time while avoiding high systemic doses associated with debilitating toxicities. The use of polymers for chemotherapy delivery expands the spectrum of available treatment of neoplasms in the central nervous system, and facilitates new approaches for the treatment of malignant gliomas. In this article, we discuss the rationale and history of the development and use of these polymers, and review the various agents that have used this technology to treat malignant brain tumors.

KW - Astrocytoma

KW - BCNU

KW - Brain tumor

KW - Chemotherapy

KW - Gliadel®

KW - Glioblastoma multiforme

KW - Glioma

KW - Implantable polymer

KW - Local drug delivery

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JO - Advanced Drug Delivery Reviews

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Local drug delivery to the brain

Abstract

Keywords

ASJC Scopus subject areas

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