TY - JOUR
T1 - Liver transplantation in the United States during the COVID-19 pandemic
T2 - National and center-level responses
AU - Strauss, Alexandra T.
AU - Boyarsky, Brian J.
AU - Garonzik-Wang, Jacqueline M.
AU - Werbel, William
AU - Durand, Christine M.
AU - Avery, Robin K.
AU - Jackson, Kyle R.
AU - Kernodle, Amber B.
AU - Baker, Talia
AU - Snyder, Jon
AU - Segev, Dorry L.
AU - Massie, Allan B.
N1 - Funding Information:
This research was made possible with generous support of the Ben-Dov family. This work was supported by grant number F32DK124941 (Boyarsky), T32AI007291 (Werbel), F32DK113719 (Jackson), F32DK117563 (Kernodle), K01KD101677 (Massie), and K23DK115908 (Garonzik-Wang) from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH). This work was supported by grant number K24AI144954 (Segev) from the National Institute of Allergy and Infectious Diseases (NIAID). The analyses described here are the responsibility of the authors alone and do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products or organizations imply endorsement by the U.S. Government. The data reported here have been supplied by the Hennepin Healthcare Research Institute (HHRI) as the contractor for the Scientific Registry of Transplant Recipients (SRTR). The interpretation and reporting of these data are the responsibilities of the author(s) and in no way should be seen as an official policy of or interpretation by the SRTR or the U.S. Government.
Funding Information:
This research was made possible with generous support of the Ben‐Dov family. This work was supported by grant number F32DK124941 (Boyarsky), T32AI007291 (Werbel), F32DK113719 (Jackson), F32DK117563 (Kernodle), K01KD101677 (Massie), and K23DK115908 (Garonzik‐Wang) from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH). This work was supported by grant number K24AI144954 (Segev) from the National Institute of Allergy and Infectious Diseases (NIAID). The analyses described here are the responsibility of the authors alone and do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products or organizations imply endorsement by the U.S. Government. The data reported here have been supplied by the Hennepin Healthcare Research Institute (HHRI) as the contractor for the Scientific Registry of Transplant Recipients (SRTR). The interpretation and reporting of these data are the responsibilities of the author(s) and in no way should be seen as an official policy of or interpretation by the SRTR or the U.S. Government.
Publisher Copyright:
© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons
PY - 2021/5
Y1 - 2021/5
N2 - COVID-19 has profoundly affected the American health care system; its effect on the liver transplant (LT) waitlist based on COVID-19 incidence has not been characterized. Using SRTR data, we compared observed LT waitlist registrations, waitlist mortality, deceased donor LTs (DDLT), and living donor LTs (LDLT) 3/15/2020-8/31/2020 to expected values based on historical trends 1/2016-1/2020, stratified by statewide COVID-19 incidence. Overall, from 3/15 to 4/30, new listings were 11% fewer than expected (IRR = 0.84 0.890.93), LDLTs were 49% fewer (IRR = 0.37 0.510.72), and DDLTs were 9% fewer (IRR = 0.85 0.910.97). In May, new listings were 21% fewer (IRR = 0.74 0.790.84), LDLTs were 42% fewer (IRR = 0.39 0.580.85) and DDLTs were 13% more (IRR = 1.07 1.151.23). Centers in states with the highest incidence 3/15-4/30 had 59% more waitlist deaths (IRR = 1.09 1.592.32) and 34% fewer DDLTs (IRR = 0.50 0.660.86). By August, waitlist outcomes were occurring at expected rates, except for DDLT (13% more across all incidences). While the early COVID-affected states endured major transplant practice changes, later in the pandemic the newly COVID-affected areas were not impacted to the same extent. These results speak to the adaptability of the transplant community in addressing the pandemic and applying new knowledge to patient care.
AB - COVID-19 has profoundly affected the American health care system; its effect on the liver transplant (LT) waitlist based on COVID-19 incidence has not been characterized. Using SRTR data, we compared observed LT waitlist registrations, waitlist mortality, deceased donor LTs (DDLT), and living donor LTs (LDLT) 3/15/2020-8/31/2020 to expected values based on historical trends 1/2016-1/2020, stratified by statewide COVID-19 incidence. Overall, from 3/15 to 4/30, new listings were 11% fewer than expected (IRR = 0.84 0.890.93), LDLTs were 49% fewer (IRR = 0.37 0.510.72), and DDLTs were 9% fewer (IRR = 0.85 0.910.97). In May, new listings were 21% fewer (IRR = 0.74 0.790.84), LDLTs were 42% fewer (IRR = 0.39 0.580.85) and DDLTs were 13% more (IRR = 1.07 1.151.23). Centers in states with the highest incidence 3/15-4/30 had 59% more waitlist deaths (IRR = 1.09 1.592.32) and 34% fewer DDLTs (IRR = 0.50 0.660.86). By August, waitlist outcomes were occurring at expected rates, except for DDLT (13% more across all incidences). While the early COVID-affected states endured major transplant practice changes, later in the pandemic the newly COVID-affected areas were not impacted to the same extent. These results speak to the adaptability of the transplant community in addressing the pandemic and applying new knowledge to patient care.
KW - clinical research/practice
KW - health services and outcomes research
KW - liver disease
KW - liver transplantation/hepatology
KW - waitlist management
UR - http://www.scopus.com/inward/record.url?scp=85096688303&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85096688303&partnerID=8YFLogxK
U2 - 10.1111/ajt.16373
DO - 10.1111/ajt.16373
M3 - Article
C2 - 33107180
AN - SCOPUS:85096688303
SN - 1600-6135
VL - 21
SP - 1838
EP - 1847
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 5
ER -