Abstract
Patients with novel coronavirus disease 2019 (COVID-19) experience various degrees of liver function abnormalities. Liver injury requires extensive work-up and continuous surveillance and can be multifactorial and heterogeneous in nature. In the context of COVID-19, clinicians will have to determine whether liver injury is related to an underlying liver disease, drugs used for the treatment of COVID-19, direct effect of the virus, or a complicated disease course. Recent studies proposed several theories on potential mechanisms of liver injury in these patients. This review summarizes current evidence related to hepatobiliary complications in COVID-19, provides an overview of the available case series and critically elucidates the proposed mechanisms and provides recommendations for clinicians.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 509-519 |
| Number of pages | 11 |
| Journal | United European Gastroenterology Journal |
| Volume | 8 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jun 1 2020 |
Keywords
- COVID-19
- SARS-CoV2
- cholangiocytes
- cytokine storm
- liver function test
- liver injury
- lymphopenia
ASJC Scopus subject areas
- Oncology
- Gastroenterology