Liver injury in COVID-19: The current evidence

Saleh A. Alqahtani, Jörn M. Schattenberg

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


Patients with novel coronavirus disease 2019 (COVID-19) experience various degrees of liver function abnormalities. Liver injury requires extensive work-up and continuous surveillance and can be multifactorial and heterogeneous in nature. In the context of COVID-19, clinicians will have to determine whether liver injury is related to an underlying liver disease, drugs used for the treatment of COVID-19, direct effect of the virus, or a complicated disease course. Recent studies proposed several theories on potential mechanisms of liver injury in these patients. This review summarizes current evidence related to hepatobiliary complications in COVID-19, provides an overview of the available case series and critically elucidates the proposed mechanisms and provides recommendations for clinicians.

Original languageEnglish (US)
Pages (from-to)509-519
Number of pages11
JournalUnited European Gastroenterology Journal
Issue number5
StatePublished - Jun 1 2020


  • COVID-19
  • SARS-CoV2
  • cholangiocytes
  • cytokine storm
  • liver function test
  • liver injury
  • lymphopenia

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology


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