Liver injury due to verapamil

J. M. Burgunder; D. R. Abernethy; B. H. Lauterburg

Liver injury due to verapamil

J. M. Burgunder, D. R. Abernethy, B. H. Lauterburg

School of Medicine

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A 56-year-old female patient on verapamil for hypertension experienced two episodes of jaundice, pruritus and upper abdominal pain with transaminase elevated up to six-fold and alkaline phosphatase up to four-fold when inadvertently re-challenged with the drug. Liver biopsy showed marked cholestasis. Verapamil can occasionally cause mixed cytotoxic-cholestatic liver injury.

Original language	English (US)
Pages (from-to)	169-170
Number of pages	2
Journal	Hepato-Gastroenterology
Volume	35
Issue number	4
State	Published - Jan 1 1988

ASJC Scopus subject areas

Hepatology
Gastroenterology

Cite this

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title = "Liver injury due to verapamil",

abstract = "A 56-year-old female patient on verapamil for hypertension experienced two episodes of jaundice, pruritus and upper abdominal pain with transaminase elevated up to six-fold and alkaline phosphatase up to four-fold when inadvertently re-challenged with the drug. Liver biopsy showed marked cholestasis. Verapamil can occasionally cause mixed cytotoxic-cholestatic liver injury.",

author = "Burgunder, {J. M.} and Abernethy, {D. R.} and Lauterburg, {B. H.}",

year = "1988",

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T1 - Liver injury due to verapamil

AU - Burgunder, J. M.

AU - Abernethy, D. R.

AU - Lauterburg, B. H.

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N2 - A 56-year-old female patient on verapamil for hypertension experienced two episodes of jaundice, pruritus and upper abdominal pain with transaminase elevated up to six-fold and alkaline phosphatase up to four-fold when inadvertently re-challenged with the drug. Liver biopsy showed marked cholestasis. Verapamil can occasionally cause mixed cytotoxic-cholestatic liver injury.

AB - A 56-year-old female patient on verapamil for hypertension experienced two episodes of jaundice, pruritus and upper abdominal pain with transaminase elevated up to six-fold and alkaline phosphatase up to four-fold when inadvertently re-challenged with the drug. Liver biopsy showed marked cholestasis. Verapamil can occasionally cause mixed cytotoxic-cholestatic liver injury.

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AN - SCOPUS:0023755086

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JO - Hepato-Gastroenterology

JF - Hepato-Gastroenterology

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ER -

Liver injury due to verapamil

Abstract

ASJC Scopus subject areas

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