The aim of this chapter is to present an up-to-date comprehensive review of pathology, pathophysiology and clinical perspectives related to liver transplantation. It is written for trained pathologists, hepatologists and transplant surgeons who are interested in developing expertise in the field of liver transplantation. Classic and unusual patterns of allograft rejection, recurrent and de novo liver diseases, technical complications, complications of immunosuppression and donor liver evaluation are illustrated in detail and emphasis is placed on biopsy interpretation. This chapter also includes contributions by experienced liver transplant surgeons and hepatologists who share their valuable expertise with pathologists to help pathologists better understand the clinical background and patient management when interpreting allograft biopsies.
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