Liquid Chromatography/Time-of-Flight Mass Spectrometry with High-Speed Integrated Transient Recording

W. Bart Emary; Ihor Lys; Richard Simpson; Andrew Hoffman; Robert J. Cotter

doi:10.1021/ac00212a022

Liquid Chromatography/Time-of-Flight Mass Spectrometry with High-Speed Integrated Transient Recording

W. Bart Emary, Ihor Lys, Richard Simpson, Andrew Hoffman, Robert J. Cotter

School of Medicine

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

High-performance liquid chromatography (HPLC) has been Interfaced to a time-of-flight mass spectrometer. The Interface Is a continuous flow probe and Ions are desorbed from the liquid matrix by energetic Ion bombardment. Pulsed and delayed Ion extraction from the source permits the use of broad Ionization times, results In the production of analog signals In each time-of-flight cycle, and provides both energy and spatial focusing. A high-speed Integrated transient recording system has been developed and is also reported. This Instrument Is the prototype for development of a high-speed, high-mass range LC detector with high duty cycle. Its performance Is demonstrated for the separation of several mixtures of small peptides.

Original language	English (US)
Pages (from-to)	1319-1324
Number of pages	6
Journal	Analytical Chemistry
Volume	62
Issue number	13
DOIs	https://doi.org/10.1021/ac00212a022
State	Published - Jul 1990

ASJC Scopus subject areas

Analytical Chemistry

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10.1021/ac00212a022

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title = "Liquid Chromatography/Time-of-Flight Mass Spectrometry with High-Speed Integrated Transient Recording",

abstract = "High-performance liquid chromatography (HPLC) has been Interfaced to a time-of-flight mass spectrometer. The Interface Is a continuous flow probe and Ions are desorbed from the liquid matrix by energetic Ion bombardment. Pulsed and delayed Ion extraction from the source permits the use of broad Ionization times, results In the production of analog signals In each time-of-flight cycle, and provides both energy and spatial focusing. A high-speed Integrated transient recording system has been developed and is also reported. This Instrument Is the prototype for development of a high-speed, high-mass range LC detector with high duty cycle. Its performance Is demonstrated for the separation of several mixtures of small peptides.",

author = "Emary, {W. Bart} and Ihor Lys and Richard Simpson and Andrew Hoffman and Cotter, {Robert J.}",

year = "1990",

month = jul,

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AU - Emary, W. Bart

AU - Lys, Ihor

AU - Simpson, Richard

AU - Hoffman, Andrew

AU - Cotter, Robert J.

PY - 1990/7

Y1 - 1990/7

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AB - High-performance liquid chromatography (HPLC) has been Interfaced to a time-of-flight mass spectrometer. The Interface Is a continuous flow probe and Ions are desorbed from the liquid matrix by energetic Ion bombardment. Pulsed and delayed Ion extraction from the source permits the use of broad Ionization times, results In the production of analog signals In each time-of-flight cycle, and provides both energy and spatial focusing. A high-speed Integrated transient recording system has been developed and is also reported. This Instrument Is the prototype for development of a high-speed, high-mass range LC detector with high duty cycle. Its performance Is demonstrated for the separation of several mixtures of small peptides.

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ER -

Liquid Chromatography/Time-of-Flight Mass Spectrometry with High-Speed Integrated Transient Recording

Abstract

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