Liquid chromatography–tandem mass spectrometry for clinical diagnostics

Stefani N. Thomas, Deborah French, Paul J. Jannetto, Brian A. Rappold, William A. Clarke

Research output: Contribution to journalArticlepeer-review


Mass spectrometry is a powerful analytical tool used for the analysis of a wide range of substances and matrices; it is increasingly utilized for clinical applications in laboratory medicine. This Primer includes an overview of basic mass spectrometry concepts, focusing primarily on tandem mass spectrometry. We discuss experimental considerations and quality management, and provide an overview of some key applications in the clinic. Lastly, the Primer discusses significant challenges for implementation of mass spectrometry in clinical laboratories and provides an outlook of where there are emerging clinical applications for this technology.

Original languageEnglish (US)
Article number96
JournalNature Reviews Methods Primers
Issue number1
StatePublished - Dec 2022

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology


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