Lipids and the pathogenesis of Alzheimer's disease: Is there a link?

M. M. Mielke, C. G. Lyketsos

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


Alzheimer's disease (AD) is a heterogeneous neurodegenerative disorder characterized pathologically by amyloid-beta plaques, neurofibrillary tangles and neuronal loss. Its fundamental cause(s) and the pathological cascades leading to clinical symptoms remain unknown. Lipids and lipid peroxidation products have important roles in the homeostasis of the central nervous system. As well, lipid transport genes and vascular changes associated with peripheral dyslipidemia have been associated with an increased risk of AD. The present review discusses ways in which lipids may be involved in the pathogenesis of AD-associated neurodegeneration through their roles as neuronal structural components, cell modulators, or second messengers. Given the many possibilities through which lipids may be directly involved in or contribute to the pathogenesis of AD, the use of lipids as biomarkers for disease progression is discussed, as are other avenues for future research.

Original languageEnglish (US)
Pages (from-to)173-186
Number of pages14
JournalInternational Review of Psychiatry
Issue number2
StatePublished - Apr 2006

ASJC Scopus subject areas

  • Psychiatry and Mental health


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