Lipid peroxidation in ethylene glycol induced hyperoxaluria and calcium oxalate nephrolithiasis

Sivagnanam Thamilselvan, Raymond L. Hackett, Saeed R. Khan

Research output: Contribution to journalArticlepeer-review

176 Scopus citations


Purpose: To determine if lipid peroxidation plays a role in renal injury associated with experimental nephrolithiasis. Materials and Methods: Hyperoxaluria was produced in rats by ethylene glycol in drinking water. At 15, 30 and 60 days of treatment, urinary oxalate, lipid peroxide, calcium oxalate crystals, enzymes and tissue lipid peroxide were measured. Results: Urinary oxalate increased significantly at all time periods and was associated with crystalluria. Lipid peroxides in kidney tissue and urine increased at all time periods. Tissue calcium oxalate crystal deposits from 0 to 1+ were present on day 15, but present in all animals on days 30 and 60. Renal tubular cell damage was confirmed by an increase in urinary marker enzymes. Conclusions: Renal cell damage is associated with lipid peroxide production indicating cell injury due to the production of free radicals. The damage appears due primarily to hyperoxaluria and is augmented by crystal deposition in the renal tubules.

Original languageEnglish (US)
Pages (from-to)1059-1063
Number of pages5
JournalJournal of Urology
Issue number3
StatePublished - Mar 1997
Externally publishedYes


  • calcium oxalate
  • hyperoxaluria
  • lipid peroxide
  • nephrolithiasis

ASJC Scopus subject areas

  • Urology


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