Lipid droplet evolution gives insight into polyaneuploid cancer cell lipid droplet functions

Laurie G. Kostecka; Kenneth J. Pienta; Sarah R. Amend

doi:10.1007/s12032-021-01584-w

Lipid droplet evolution gives insight into polyaneuploid cancer cell lipid droplet functions

Laurie G. Kostecka, Kenneth J. Pienta, Sarah R. Amend

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Lipid droplets (LDs) are found throughout all phyla across the tree of life. Originating as pure energy stores in the most basic organisms, LDs have evolved to fill various roles as regulators of lipid metabolism, signaling, and trafficking. LDs have been noted in cancer cells and have shown to increase tumor aggressiveness and chemotherapy resistance. A certain transitory state of cancer cell, the polyaneuploid cancer cell (PACC), appears to have higher LD levels than the cancer cell from which they are derived. PACCs are postulated to be the mediators of metastasis and resistance in many different cancers. Utilizing the evolutionarily conserved roles of LDs to protect from cellular lipotoxicity allows PACCs to survive otherwise lethal stressors. By better understanding how LDs have evolved throughout different phyla we will identify opportunities to target LDs in PACCs to increase therapeutic efficiency in cancer cells.

Original language	English (US)
Article number	133
Journal	Medical Oncology
Volume	38
Issue number	11
DOIs	https://doi.org/10.1007/s12032-021-01584-w
State	Published - Nov 2021

Keywords

Evolution
Lipid droplets
Polyaneuploid cancer cells
Polyploid giant cancer cells
Therapy resistance

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1007/s12032-021-01584-w

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title = "Lipid droplet evolution gives insight into polyaneuploid cancer cell lipid droplet functions",

abstract = "Lipid droplets (LDs) are found throughout all phyla across the tree of life. Originating as pure energy stores in the most basic organisms, LDs have evolved to fill various roles as regulators of lipid metabolism, signaling, and trafficking. LDs have been noted in cancer cells and have shown to increase tumor aggressiveness and chemotherapy resistance. A certain transitory state of cancer cell, the polyaneuploid cancer cell (PACC), appears to have higher LD levels than the cancer cell from which they are derived. PACCs are postulated to be the mediators of metastasis and resistance in many different cancers. Utilizing the evolutionarily conserved roles of LDs to protect from cellular lipotoxicity allows PACCs to survive otherwise lethal stressors. By better understanding how LDs have evolved throughout different phyla we will identify opportunities to target LDs in PACCs to increase therapeutic efficiency in cancer cells.",

keywords = "Evolution, Lipid droplets, Polyaneuploid cancer cells, Polyploid giant cancer cells, Therapy resistance",

author = "Kostecka, {Laurie G.} and Pienta, {Kenneth J.} and Amend, {Sarah R.}",

note = "Funding Information: This work was supported by the US Department of Defense CDMRP/PCRP (W81XWH-20-10353), the Patrick C. Walsh Prostate Cancer Research Fund and the Prostate Cancer Foundation to SA; and NCI Grants U54CA143803, CA163124, 783 CA093900, and CA143055, and the Prostate Cancer Foundation to KP. This work was also supported by the William and Carolyn Stutt Re-search Fund, Ronald Rose, MC Dean, Inc., William and Marjorie Springer, Mary and Dave Stevens, Louis Dorfman, and the Jones Family Foundation. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = nov,

doi = "10.1007/s12032-021-01584-w",

language = "English (US)",

volume = "38",

journal = "Medical Oncology",

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AU - Kostecka, Laurie G.

AU - Pienta, Kenneth J.

AU - Amend, Sarah R.

N1 - Funding Information: This work was supported by the US Department of Defense CDMRP/PCRP (W81XWH-20-10353), the Patrick C. Walsh Prostate Cancer Research Fund and the Prostate Cancer Foundation to SA; and NCI Grants U54CA143803, CA163124, 783 CA093900, and CA143055, and the Prostate Cancer Foundation to KP. This work was also supported by the William and Carolyn Stutt Re-search Fund, Ronald Rose, MC Dean, Inc., William and Marjorie Springer, Mary and Dave Stevens, Louis Dorfman, and the Jones Family Foundation. Publisher Copyright: © 2021, The Author(s).

PY - 2021/11

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N2 - Lipid droplets (LDs) are found throughout all phyla across the tree of life. Originating as pure energy stores in the most basic organisms, LDs have evolved to fill various roles as regulators of lipid metabolism, signaling, and trafficking. LDs have been noted in cancer cells and have shown to increase tumor aggressiveness and chemotherapy resistance. A certain transitory state of cancer cell, the polyaneuploid cancer cell (PACC), appears to have higher LD levels than the cancer cell from which they are derived. PACCs are postulated to be the mediators of metastasis and resistance in many different cancers. Utilizing the evolutionarily conserved roles of LDs to protect from cellular lipotoxicity allows PACCs to survive otherwise lethal stressors. By better understanding how LDs have evolved throughout different phyla we will identify opportunities to target LDs in PACCs to increase therapeutic efficiency in cancer cells.

AB - Lipid droplets (LDs) are found throughout all phyla across the tree of life. Originating as pure energy stores in the most basic organisms, LDs have evolved to fill various roles as regulators of lipid metabolism, signaling, and trafficking. LDs have been noted in cancer cells and have shown to increase tumor aggressiveness and chemotherapy resistance. A certain transitory state of cancer cell, the polyaneuploid cancer cell (PACC), appears to have higher LD levels than the cancer cell from which they are derived. PACCs are postulated to be the mediators of metastasis and resistance in many different cancers. Utilizing the evolutionarily conserved roles of LDs to protect from cellular lipotoxicity allows PACCs to survive otherwise lethal stressors. By better understanding how LDs have evolved throughout different phyla we will identify opportunities to target LDs in PACCs to increase therapeutic efficiency in cancer cells.

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KW - Polyaneuploid cancer cells

KW - Polyploid giant cancer cells

KW - Therapy resistance

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Lipid droplet evolution gives insight into polyaneuploid cancer cell lipid droplet functions

Abstract

Keywords

ASJC Scopus subject areas

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