Linezolid and lactic acidosis: A role for lactate monitoring with long-term linezolid use in children

Erik Su; Kelli Crowley; Joseph A. Carcillo; Marian G. Michaels

doi:10.1097/INF.0b013e3182186035

Linezolid and lactic acidosis: A role for lactate monitoring with long-term linezolid use in children

Erik Su, Kelli Crowley, Joseph A. Carcillo, Marian G. Michaels

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Linezolid administration has been associated with lactic acidosis in adults; however, the same phenomenon has not been reported in children. Mitochondrial protein synthesis inhibition is a demonstrated mechanism for toxicity, which therefore may manifest as lactic acidosis. Three cases of linezolid-associated lactic acidosis in children are reported to reinforce the need for pediatric caregivers to be vigilant of this potential side effect.

Original language	English (US)
Pages (from-to)	804-806
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	30
Issue number	9
DOIs	https://doi.org/10.1097/INF.0b013e3182186035
State	Published - Sep 2011
Externally published	Yes

Keywords

Pediatric
lactic acidosis
linezolid
mitochondria
multidrug resistance
vancomycin-resistant Enterococcus

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

Access to Document

10.1097/INF.0b013e3182186035

Cite this

@article{26906be031554c2f8d24da85d80160f3,

title = "Linezolid and lactic acidosis: A role for lactate monitoring with long-term linezolid use in children",

abstract = "Linezolid administration has been associated with lactic acidosis in adults; however, the same phenomenon has not been reported in children. Mitochondrial protein synthesis inhibition is a demonstrated mechanism for toxicity, which therefore may manifest as lactic acidosis. Three cases of linezolid-associated lactic acidosis in children are reported to reinforce the need for pediatric caregivers to be vigilant of this potential side effect.",

keywords = "Pediatric, lactic acidosis, linezolid, mitochondria, multidrug resistance, vancomycin-resistant Enterococcus",

author = "Erik Su and Kelli Crowley and Carcillo, {Joseph A.} and Michaels, {Marian G.}",

note = "Funding Information: Supported in part by T32HD040686. ",

year = "2011",

month = sep,

doi = "10.1097/INF.0b013e3182186035",

language = "English (US)",

volume = "30",

pages = "804--806",

journal = "Pediatric Infectious Disease Journal",

issn = "0891-3668",

publisher = "Lippincott Williams and Wilkins",

number = "9",

}

TY - JOUR

T1 - Linezolid and lactic acidosis

T2 - A role for lactate monitoring with long-term linezolid use in children

AU - Su, Erik

AU - Crowley, Kelli

AU - Carcillo, Joseph A.

AU - Michaels, Marian G.

N1 - Funding Information: Supported in part by T32HD040686.

PY - 2011/9

Y1 - 2011/9

N2 - Linezolid administration has been associated with lactic acidosis in adults; however, the same phenomenon has not been reported in children. Mitochondrial protein synthesis inhibition is a demonstrated mechanism for toxicity, which therefore may manifest as lactic acidosis. Three cases of linezolid-associated lactic acidosis in children are reported to reinforce the need for pediatric caregivers to be vigilant of this potential side effect.

AB - Linezolid administration has been associated with lactic acidosis in adults; however, the same phenomenon has not been reported in children. Mitochondrial protein synthesis inhibition is a demonstrated mechanism for toxicity, which therefore may manifest as lactic acidosis. Three cases of linezolid-associated lactic acidosis in children are reported to reinforce the need for pediatric caregivers to be vigilant of this potential side effect.

KW - Pediatric

KW - lactic acidosis

KW - linezolid

KW - mitochondria

KW - multidrug resistance

KW - vancomycin-resistant Enterococcus

UR - http://www.scopus.com/inward/record.url?scp=80051939093&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051939093&partnerID=8YFLogxK

U2 - 10.1097/INF.0b013e3182186035

DO - 10.1097/INF.0b013e3182186035

M3 - Article

C2 - 21852764

AN - SCOPUS:80051939093

SN - 0891-3668

VL - 30

SP - 804

EP - 806

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 9

ER -

Linezolid and lactic acidosis: A role for lactate monitoring with long-term linezolid use in children

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this