Limited effect of trimethoprim-sulfamethoxazole prophylaxis on Pneumocystis carinii

W. T. Hughes

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Trimethoprim-sulfamethoxazole has been proven effective in the treatment and prevention of Pneumocystis carinii pneumonitis in lower animals and humans. How effective the drug combination is in eradicating P. carinii from the host is not known. The immunosuppressed rat model was used to determine whether or not trimethoprim-sulfamethoxazole effectively eradicated the organism. Animals treated with trimethoprim-sulfamethoxazole for as long as 6 weeks were then placed in individual isolater cages, immunosuppressed with prednisolone for 12 weeks, and sacrified. P. carinii was found in the lungs of at least 90% of the drug-treated as well as untreated control groups. The data indicate that trimethoprim-sulfamethoxazole has a limited rather than a lethal effect on P. carinii and that protection is afforded only during the period of trimethoprim-sulfamethoxazole administration.

Original languageEnglish (US)
Pages (from-to)333-335
Number of pages3
JournalAntimicrobial agents and chemotherapy
Issue number3
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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