Limited dermal ossification: Clinical features and natural history

Carol M. Foster, Sondra Levin, Michael Levine, Anil Mukherjee, Jonathan L. Costa, Edward D. Eanes, Timothy Triche, Michael Zasloff

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


For 9 years we have observed a girl who has ossification in the dermis with astrikingly limited distribution. Recently a second girl with similar dermal ossification restricted to a single extremity was identified. The ectopic bone is histologically identical to normal membranous bone. These two patients have no obvious underlying cause for soft tissue bone formation, and no disorder of calcium or phosphate metabolism. Ossification first involved the dermal and subcutaneous connective tissue, and with time advanced locally in the affected areas to bridge joints and limit mobility. The ossification has now extended to involve muscle fascia but has not involved the muscle itself. This disease appears to represent a heretofore unrecognized disorder of mesenchymal differentiation.

Original languageEnglish (US)
Pages (from-to)71-76
Number of pages6
JournalJournal of Pediatrics
Issue number1
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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