Limited added value of oropharyngeal swabs for detecting pneumococcal carriage in adults

Jennifer L. Farrar; Herine Odiembo; Arthur Odoyo; Godfrey Bigogo; Lindsay Kim; Fernanda C. Lessa; Daniel R. Feikin; Robert F. Breiman; Cynthia G. Whitney; Maria G. Carvalho; Fabiana C. Pimenta

doi:10.1093/ofid/ofaa368

Limited added value of oropharyngeal swabs for detecting pneumococcal carriage in adults

Jennifer L. Farrar, Herine Odiembo, Arthur Odoyo, Godfrey Bigogo, Lindsay Kim, Fernanda C. Lessa, Daniel R. Feikin, Robert F. Breiman, Cynthia G. Whitney, Maria G. Carvalho, Fabiana C. Pimenta

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We compared pneumococcal isolation rates and evaluated the benefit of using oropharyngeal (OP) specimens in addition to nasopharyngeal (NP) specimens collected from adults in rural Kenya. Of 846 adults, 52.1% were colonized; pneumococci were detected from both NP and OP specimens in 23.5%, NP only in 22.9%, and OP only in 5.7%. Ten-valent pneumococcal conjugate vaccine strains were detected from both NP and OP in 3.4%, NP only in 4.1%, and OP only in 0.7%. Inclusion of OP swabs increased carriage detection by 5.7%; however, the added cost of collecting and processing OP specimens may justify exclusion from future carriage studies among adults.

Original language	English (US)
Article number	ofaa368
Journal	Open Forum Infectious Diseases
Volume	7
Issue number	9
DOIs	https://doi.org/10.1093/ofid/ofaa368
State	Published - Sep 1 2020

Keywords

Adults
Carriage
Colonization
Nasopharyngeal
Oropharyngeal
Streptococcus pneumoniae

ASJC Scopus subject areas

Oncology
Clinical Neurology

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title = "Limited added value of oropharyngeal swabs for detecting pneumococcal carriage in adults",

abstract = "We compared pneumococcal isolation rates and evaluated the benefit of using oropharyngeal (OP) specimens in addition to nasopharyngeal (NP) specimens collected from adults in rural Kenya. Of 846 adults, 52.1% were colonized; pneumococci were detected from both NP and OP specimens in 23.5%, NP only in 22.9%, and OP only in 5.7%. Ten-valent pneumococcal conjugate vaccine strains were detected from both NP and OP in 3.4%, NP only in 4.1%, and OP only in 0.7%. Inclusion of OP swabs increased carriage detection by 5.7%; however, the added cost of collecting and processing OP specimens may justify exclusion from future carriage studies among adults.",

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doi = "10.1093/ofid/ofaa368",

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AU - Odiembo, Herine

AU - Odoyo, Arthur

AU - Bigogo, Godfrey

AU - Kim, Lindsay

AU - Lessa, Fernanda C.

AU - Feikin, Daniel R.

AU - Breiman, Robert F.

AU - Whitney, Cynthia G.

AU - Carvalho, Maria G.

AU - Pimenta, Fabiana C.

N1 - Funding Information: This work was supported in part by the Bill and Melinda Gates Foundation and the United States Agency for International Development. Publisher Copyright: © 2020 The Author(s).

PY - 2020/9/1

Y1 - 2020/9/1

N2 - We compared pneumococcal isolation rates and evaluated the benefit of using oropharyngeal (OP) specimens in addition to nasopharyngeal (NP) specimens collected from adults in rural Kenya. Of 846 adults, 52.1% were colonized; pneumococci were detected from both NP and OP specimens in 23.5%, NP only in 22.9%, and OP only in 5.7%. Ten-valent pneumococcal conjugate vaccine strains were detected from both NP and OP in 3.4%, NP only in 4.1%, and OP only in 0.7%. Inclusion of OP swabs increased carriage detection by 5.7%; however, the added cost of collecting and processing OP specimens may justify exclusion from future carriage studies among adults.

AB - We compared pneumococcal isolation rates and evaluated the benefit of using oropharyngeal (OP) specimens in addition to nasopharyngeal (NP) specimens collected from adults in rural Kenya. Of 846 adults, 52.1% were colonized; pneumococci were detected from both NP and OP specimens in 23.5%, NP only in 22.9%, and OP only in 5.7%. Ten-valent pneumococcal conjugate vaccine strains were detected from both NP and OP in 3.4%, NP only in 4.1%, and OP only in 0.7%. Inclusion of OP swabs increased carriage detection by 5.7%; however, the added cost of collecting and processing OP specimens may justify exclusion from future carriage studies among adults.

KW - Adults

KW - Carriage

KW - Colonization

KW - Nasopharyngeal

KW - Oropharyngeal

KW - Streptococcus pneumoniae

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Limited added value of oropharyngeal swabs for detecting pneumococcal carriage in adults

Abstract

Keywords

ASJC Scopus subject areas

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