Light Transmission Aggregometry

Paul A. Gurbel, Martin Gesheff, Kevin P. Bliden, Udaya S. Tantry

Research output: Chapter in Book/Report/Conference proceedingChapter


Laboratory evaluation of platelet function by a simple and reliable in vitro method is crucial to understand the critical role of platelets during hemostasis and thrombotic complications of cardiovascular disease. An in vitro quantitative determination of platelet aggregation by the light transmittance aggregometry (LTA) and the important role of adenosine diphosphate (ADP) during platelet aggregation were first described by Born. Despite its limitations, LTA is still considered as the "gold standard assay" for platelet function measurement. In addition to the assessment of antiplatelet drug response, LTA is also used to study bleeding disorders and congenital or acquired disorders of platelet receptors.

Original languageEnglish (US)
Title of host publicationAntiplatelet Therapy in Cardiovascular Disease
Number of pages7
ISBN (Electronic)9781118493984
ISBN (Print)9781118275757
StatePublished - Jun 3 2014
Externally publishedYes


  • Adenosine diphosphate
  • Anticoagulant
  • Antiplatelet drug response
  • Bleeding disorder
  • Light transmittance
  • Platelet aggregation

ASJC Scopus subject areas

  • Medicine(all)


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