Light-induced changes in pineal hydroxyindole-O-methyltransferase: Abolition by lateral hypothalamic lesions

Julius Axelrod; Solomon H. Snyder; Alfred Heller; Robert Y. Moore

doi:10.1126/science.154.3751.898

Light-induced changes in pineal hydroxyindole-O-methyltransferase: Abolition by lateral hypothalamic lesions

Julius Axelrod, Solomon H. Snyder, Alfred Heller, Robert Y. Moore

School of Medicine

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The activity of hydroxyindole-O-methyltransferase, the melatonin-forming enzyme in the pineal gland, is several times greater in rats kept in continuous darkness than in those kept in continuous light. Lesions transecting the medial forebrain bundle in the lateral hypothalamus suppress these differences in enzyme activity and abolish light-induced changes in pineal weight. These findings indicate that the medial forebrain bundle may participate in the control of this enzymatic response to environmental lighting.

Original language	English (US)
Pages (from-to)	898-899
Number of pages	2
Journal	Science
Volume	154
Issue number	3751
DOIs	https://doi.org/10.1126/science.154.3751.898
State	Published - 1966

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title = "Light-induced changes in pineal hydroxyindole-O-methyltransferase: Abolition by lateral hypothalamic lesions",

abstract = "The activity of hydroxyindole-O-methyltransferase, the melatonin-forming enzyme in the pineal gland, is several times greater in rats kept in continuous darkness than in those kept in continuous light. Lesions transecting the medial forebrain bundle in the lateral hypothalamus suppress these differences in enzyme activity and abolish light-induced changes in pineal weight. These findings indicate that the medial forebrain bundle may participate in the control of this enzymatic response to environmental lighting.",

author = "Julius Axelrod and Snyder, {Solomon H.} and Alfred Heller and Moore, {Robert Y.}",

year = "1966",

doi = "10.1126/science.154.3751.898",

language = "English (US)",

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T1 - Light-induced changes in pineal hydroxyindole-O-methyltransferase

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AU - Axelrod, Julius

AU - Snyder, Solomon H.

AU - Heller, Alfred

AU - Moore, Robert Y.

PY - 1966

Y1 - 1966

N2 - The activity of hydroxyindole-O-methyltransferase, the melatonin-forming enzyme in the pineal gland, is several times greater in rats kept in continuous darkness than in those kept in continuous light. Lesions transecting the medial forebrain bundle in the lateral hypothalamus suppress these differences in enzyme activity and abolish light-induced changes in pineal weight. These findings indicate that the medial forebrain bundle may participate in the control of this enzymatic response to environmental lighting.

AB - The activity of hydroxyindole-O-methyltransferase, the melatonin-forming enzyme in the pineal gland, is several times greater in rats kept in continuous darkness than in those kept in continuous light. Lesions transecting the medial forebrain bundle in the lateral hypothalamus suppress these differences in enzyme activity and abolish light-induced changes in pineal weight. These findings indicate that the medial forebrain bundle may participate in the control of this enzymatic response to environmental lighting.

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Light-induced changes in pineal hydroxyindole-O-methyltransferase: Abolition by lateral hypothalamic lesions

Abstract

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