Life-threatening status asthmaticus treated with inhaled nitric oxide

Thomas A. Nakagawa, Santa J. Johnston, Sheryl A. Falkos, Robert J. Gomez, Amelia Morris

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Inhaled nitric oxide (NO) was administered to 5 consecutive children with life-threatening status asthmaticus who required mechanical ventilation and did not respond to maximal medical management. Four showed a >20% decrease in baseline PaCO2 (median PaCO2 = 154 mm Hg, range = 95 to 229 mm Hg) occurring rapidly after the administration of inhaled NO. Three children, in addition to the index case, received continuous inhaled NO therapy, ranging from 5.5 to 21.5 hours. Systemic hypotension was not observed, and the maximum methemoglobin level was 1.9%. Four children survived to hospital discharge. Although the precise mechanism of action is not known, it appears that inhaled NO merits further study and may represent a life-saving therapy in this select patient population.

Original languageEnglish (US)
Pages (from-to)119-122
Number of pages4
JournalJournal of Pediatrics
Issue number1
StatePublished - Jul 2000
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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