Life events and the course of bipolar disorder

Aimee Ellicott, Constance Hammen, Michael Gitlin, Gary Brown, Kay Jamison

Research output: Contribution to journalArticlepeer-review

200 Scopus citations


The authors examined the impact of life stress on the course of bipolar disorder over a 2-year period in a group of 61 outpatients. The patients were followed prospectively with ongoing assessments of stressful life events, symptoms, levels of maintenance medication, and compliance with treatment regimens. As predicted, survival analyses indicated a significant association between life events and relapse or recurrence of the disorder. These effects could not be explained by differences in levels of medication or compliance. Further research is recommended to examine which specific subgroups of bipolar patients are most susceptible to stress.

Original languageEnglish (US)
Pages (from-to)1194-1198
Number of pages5
JournalAmerican Journal of Psychiatry
Issue number9
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


Dive into the research topics of 'Life events and the course of bipolar disorder'. Together they form a unique fingerprint.

Cite this