Leydig cell steroidogenesis in aging rats

B. R. Zirkin; H. Chen; L. Luo

doi:10.1016/S0531-5565(96)00165-9

Leydig cell steroidogenesis in aging rats

B. R. Zirkin, H. Chen, L. Luo

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Recent studies from our and other laboratories have shown that Leydig cells, the testicular cells responsible for testosterone production, become steroidogenically hypofunctional with age. Herein we review some of what we now know about the mechanisms by which this occurs, and some among the many remaining uncertainties in our understanding of Leydig cell aging. To help shed light on how Leydig cells age, we also briefly discuss the regulation of Leydig cell differentiation during puberty and of Leydig cell function in adult animals.

Original language	English (US)
Pages (from-to)	529-537
Number of pages	9
Journal	Experimental Gerontology
Volume	32
Issue number	4-5
DOIs	https://doi.org/10.1016/S0531-5565(96)00165-9
State	Published - Jul 1997
Externally published	Yes

Keywords

Aging
Leydig cell
Rat
Steroidogenesis
Testosterone

ASJC Scopus subject areas

Biochemistry
Aging
Molecular Biology
Genetics
Endocrinology
Cell Biology

Access to Document

10.1016/S0531-5565(96)00165-9

Cite this

@article{ed9a1778aa0b4fcbad9479ed55936669,

title = "Leydig cell steroidogenesis in aging rats",

abstract = "Recent studies from our and other laboratories have shown that Leydig cells, the testicular cells responsible for testosterone production, become steroidogenically hypofunctional with age. Herein we review some of what we now know about the mechanisms by which this occurs, and some among the many remaining uncertainties in our understanding of Leydig cell aging. To help shed light on how Leydig cells age, we also briefly discuss the regulation of Leydig cell differentiation during puberty and of Leydig cell function in adult animals.",

keywords = "Aging, Leydig cell, Rat, Steroidogenesis, Testosterone",

author = "Zirkin, {B. R.} and H. Chen and L. Luo",

year = "1997",

month = jul,

doi = "10.1016/S0531-5565(96)00165-9",

language = "English (US)",

volume = "32",

pages = "529--537",

journal = "Experimental Gerontology",

issn = "0531-5565",

publisher = "Elsevier Inc.",

number = "4-5",

}

TY - JOUR

T1 - Leydig cell steroidogenesis in aging rats

AU - Zirkin, B. R.

AU - Chen, H.

AU - Luo, L.

PY - 1997/7

Y1 - 1997/7

N2 - Recent studies from our and other laboratories have shown that Leydig cells, the testicular cells responsible for testosterone production, become steroidogenically hypofunctional with age. Herein we review some of what we now know about the mechanisms by which this occurs, and some among the many remaining uncertainties in our understanding of Leydig cell aging. To help shed light on how Leydig cells age, we also briefly discuss the regulation of Leydig cell differentiation during puberty and of Leydig cell function in adult animals.

AB - Recent studies from our and other laboratories have shown that Leydig cells, the testicular cells responsible for testosterone production, become steroidogenically hypofunctional with age. Herein we review some of what we now know about the mechanisms by which this occurs, and some among the many remaining uncertainties in our understanding of Leydig cell aging. To help shed light on how Leydig cells age, we also briefly discuss the regulation of Leydig cell differentiation during puberty and of Leydig cell function in adult animals.

KW - Aging

KW - Leydig cell

KW - Rat

KW - Steroidogenesis

KW - Testosterone

UR - http://www.scopus.com/inward/record.url?scp=0030843138&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030843138&partnerID=8YFLogxK

U2 - 10.1016/S0531-5565(96)00165-9

DO - 10.1016/S0531-5565(96)00165-9

M3 - Article

C2 - 9315454

AN - SCOPUS:0030843138

SN - 0531-5565

VL - 32

SP - 529

EP - 537

JO - Experimental Gerontology

JF - Experimental Gerontology

IS - 4-5

ER -

Leydig cell steroidogenesis in aging rats

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this