TY - CHAP
T1 - Leveraging Tissue Engineering for Skin Cancer Models
AU - Oudda, Sumayah
AU - Ali, Abdulla M.
AU - Chien, Anna L.
AU - Park, Seungman
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.
PY - 2023
Y1 - 2023
N2 - Bioengineered in vitro three-dimensional (3D) skin model has emerged as a promising tool for recapitulating different types of skin cancer and performing pre-clinical tests. However, a full-thickness 3D model including the epidermis, dermis, and hypodermis layers is scarce despite its significance in human physiology and diverse biological processes. In this book chapter, an attempt has been made to summarize various skin cancer models, including utilized skin layers, materials, cell lines, specific treatments, and fabrication techniques for three types of skin cancer: melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). Subsequently, current limitations and future directions of skin cancer models are discussed. The knowledge of the current status of skin cancer models can provide various potential applications in cancer research and thus a more effective way for cancer treatment.
AB - Bioengineered in vitro three-dimensional (3D) skin model has emerged as a promising tool for recapitulating different types of skin cancer and performing pre-clinical tests. However, a full-thickness 3D model including the epidermis, dermis, and hypodermis layers is scarce despite its significance in human physiology and diverse biological processes. In this book chapter, an attempt has been made to summarize various skin cancer models, including utilized skin layers, materials, cell lines, specific treatments, and fabrication techniques for three types of skin cancer: melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). Subsequently, current limitations and future directions of skin cancer models are discussed. The knowledge of the current status of skin cancer models can provide various potential applications in cancer research and thus a more effective way for cancer treatment.
KW - Basal cell carcinoma (BCC)
KW - In vitro 3D model
KW - Melanoma
KW - Skin cancer
KW - Squamous cell carcinoma (SCC)
UR - http://www.scopus.com/inward/record.url?scp=85151042592&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85151042592&partnerID=8YFLogxK
U2 - 10.1007/5584_2022_755
DO - 10.1007/5584_2022_755
M3 - Chapter
C2 - 36484897
AN - SCOPUS:85151042592
T3 - Advances in Experimental Medicine and Biology
SP - 97
EP - 113
BT - Advances in Experimental Medicine and Biology
PB - Springer
ER -