Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model

Q. Q. Quartey; R. J. Miller; B. L. Pinsker; U. J. Okoh; W. D. Shipman; B. A. George; C. C. Nwizu; L. A. Barnes; M. L. Kerns; J. A. Caffrey; O. Aliu; I. D. Brown; F. Succaria; J. P. Maynard; A. S. Herbert; S. Kang; L. S. Miller; G. A. Okoye; A. S. Byrd

doi:10.1111/ced.14054

Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model

Q. Q. Quartey, R. J. Miller, B. L. Pinsker, U. J. Okoh, W. D. Shipman, B. A. George, C. C. Nwizu, L. A. Barnes, M. L. Kerns, J. A. Caffrey, O. Aliu, I. D. Brown, F. Succaria, J. P. Maynard, A. S. Herbert, S. Kang, L. S. Miller, G. A. Okoye, A. S. Byrd

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease originating from the pilosebaceous unit, in which patients develop painful abscesses, sinus tracts, nodules and scarring, typically in intertriginous areas. Major gaps in our understanding of HS exist, and these may be partially due to the lack of an animal model for experimental studies. We developed an HS xenograft mouse model using human HS lesions grafted onto immunocompromised mice. Although the model had its limitations, several informative lessons were learned, which may contribute to future attempts at an HS animal model.

Original language	English (US)
Pages (from-to)	202-206
Number of pages	5
Journal	Clinical and Experimental Dermatology
Volume	45
Issue number	2
DOIs	https://doi.org/10.1111/ced.14054
State	Published - Mar 1 2020

ASJC Scopus subject areas

Dermatology

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Quartey, Q. Q., Miller, R. J., Pinsker, B. L., Okoh, U. J., Shipman, W. D., George, B. A., Nwizu, C. C., Barnes, L. A., Kerns, M. L., Caffrey, J. A., Aliu, O., Brown, I. D., Succaria, F., Maynard, J. P., Herbert, A. S., Kang, S., Miller, L. S., Okoye, G. A., & Byrd, A. S. (2020). Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model. Clinical and Experimental Dermatology, 45(2), 202-206. https://doi.org/10.1111/ced.14054

Quartey, QQ, Miller, RJ, Pinsker, BL, Okoh, UJ, Shipman, WD, George, BA, Nwizu, CC, Barnes, LA, Kerns, ML, Caffrey, JA, Aliu, O, Brown, ID, Succaria, F , Maynard, JP, Herbert, AS, Kang, S, Miller, LS, Okoye, GA & Byrd, AS 2020, 'Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model', Clinical and Experimental Dermatology, vol. 45, no. 2, pp. 202-206. https://doi.org/10.1111/ced.14054

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title = "Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model",

abstract = "Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease originating from the pilosebaceous unit, in which patients develop painful abscesses, sinus tracts, nodules and scarring, typically in intertriginous areas. Major gaps in our understanding of HS exist, and these may be partially due to the lack of an animal model for experimental studies. We developed an HS xenograft mouse model using human HS lesions grafted onto immunocompromised mice. Although the model had its limitations, several informative lessons were learned, which may contribute to future attempts at an HS animal model.",

author = "Quartey, {Q. Q.} and Miller, {R. J.} and Pinsker, {B. L.} and Okoh, {U. J.} and Shipman, {W. D.} and George, {B. A.} and Nwizu, {C. C.} and Barnes, {L. A.} and Kerns, {M. L.} and Caffrey, {J. A.} and O. Aliu and Brown, {I. D.} and F. Succaria and Maynard, {J. P.} and Herbert, {A. S.} and S. Kang and Miller, {L. S.} and Okoye, {G. A.} and Byrd, {A. S.}",

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AU - Okoh, U. J.

AU - Shipman, W. D.

AU - George, B. A.

AU - Nwizu, C. C.

AU - Barnes, L. A.

AU - Kerns, M. L.

AU - Caffrey, J. A.

AU - Aliu, O.

AU - Brown, I. D.

AU - Succaria, F.

AU - Maynard, J. P.

AU - Herbert, A. S.

AU - Kang, S.

AU - Miller, L. S.

AU - Okoye, G. A.

AU - Byrd, A. S.

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AB - Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease originating from the pilosebaceous unit, in which patients develop painful abscesses, sinus tracts, nodules and scarring, typically in intertriginous areas. Major gaps in our understanding of HS exist, and these may be partially due to the lack of an animal model for experimental studies. We developed an HS xenograft mouse model using human HS lesions grafted onto immunocompromised mice. Although the model had its limitations, several informative lessons were learned, which may contribute to future attempts at an HS animal model.

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Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model

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