Lessons learned from next-generation sequencing in head and neck cancer

Myriam Loyo, Ryan J. Li, Chetan Bettegowda, Curtis R. Pickering, Mitchell J. Frederick, Jeffrey N. Myers, Nishant Agrawal

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


Scientific innovation has enabled whole exome capture and massively parallel sequencing of cancer genomes. In head and neck cancer, next-generation sequencing has granted us further understanding of the mutational spectrum of squamous cell carcinoma. As a result of these new technologies, frequently occurring mutations were identified in NOTCH1, a gene that had not previously been implicated in head and neck cancer. The current review describes the most common mutations in head and neck cancer: TP53, NOTCH1, HRAS, PIK3CA, and CDKN2A. Emphasis is placed on the involved cellular pathways, clinical correlations, and potential therapeutic interventions. Additionally, the implications of human papillomavirus on mutation patterns are discussed.

Original languageEnglish (US)
Pages (from-to)454-463
Number of pages10
JournalHead and Neck
Issue number3
StatePublished - Mar 2013


  • head and neck squamous cell carcinoma
  • mutations
  • next generation sequencing
  • oncogene
  • tumor suppressor gene

ASJC Scopus subject areas

  • Otorhinolaryngology


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