Lesion quantification in dual-modality mammotomography

Heng Li, Yibin Zheng, Mitali J. More, Patricia J. Goodale, Mark B. Williams

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


This paper describes a novel x-ray/SPECT dual modality breast imaging system that provides 3D structural and functional information. While only a limited number of views on one side of the breast can be acquired due to mechanical and time constraints, we developed a technique to compensate for the limited angle artifact in reconstruction images and accurately estimate both the lesion size and radioactivity concentration. Various angular sampling strategies were evaluated using both simulated and experimental data. It was demonstrated that quantification of lesion size to an accuracy of 10% and quantification of radioactivity to an accuracy of 20% are feasible from limited-angle data acquired with clinically practical dosage and acquisition time.

Original languageEnglish (US)
Pages (from-to)107-115
Number of pages9
JournalIEEE Transactions on Nuclear Science
Issue number1
StatePublished - Feb 2007
Externally publishedYes


  • Breast imaging
  • Dual modality imaging
  • Image reconstruction
  • Tumor quantification

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Nuclear Energy and Engineering
  • Electrical and Electronic Engineering


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