Lesion characteristics and depressed mood in the Stroke Data Bank study

Philip L.P. Morris, Robert G. Robinson, Max L. De Carvalho, Paul Albert, Jane C. Wells, Jack F. Samuels, Diane Eden-Fetzer, Thomas R. Price

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


This study examined the relationship between post-stroke lesion size and location and depressed mood by using data from the multicenter National Stroke Data Bank. For inpatients with first-ever cerebral infarction, lesions were characterized by location and size from CT scans. Forty-seven (24%) of the 193 patients studied were depressed. In the complete sample, neither lesion size nor location was associated with depression. However, among patients with comparable small-sized lesions (n = 124), depression was more frequent among those with left hemisphere stroke than those with right hemisphere stroke (31% vs. 16%; P = 0.04). Among patients with larger lesions, brain edema was common and may have obscured lateralized findings. Different biogenic amine neurotransmitter responses to right and left hemisphere brain injury may underlie this mood asymmetry.

Original languageEnglish (US)
Pages (from-to)153-159
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number2
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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