Leptin signaling

Hyeong Kyu Park, Rexford S. Ahima

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations


Leptin is secreted by adipose tissue and regulates energy homeostasis, glucose and lipid metabolism, immune function, and other systems. The binding of leptin to its specific receptor activates various intracellular signaling pathways, including Janus kinase 2 (JAK2)/ signal transducer and activator of transcription 3 (STAT3), insulin receptor substrate (IRS)/phosphatidylinositol 3 kinase (PI3K), SH2-containing protein tyrosine phosphatase 2 (SHP2)/mitogen-activated protein kinase (MAPK), and 5′ adenosine monophosphate-activated protein kinase (AMPK)/ acetyl-CoA carboxylase (ACC), in the central nervous system and peripheral tissues. Understanding of leptin signaling provides insights into its roles in health and disease.

Original languageEnglish (US)
Article number73
JournalF1000Prime Reports
StatePublished - 2014
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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