Leflunomide: Is there a place for its use in transplantation?

Matthew J. Koch; Daniel C. Brennan

doi:10.1097/00075200-200312000-00010

Leflunomide: Is there a place for its use in transplantation?

Matthew J. Koch, Daniel C. Brennan

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Leflunomide has several properties that make it an excellent candidate for use in transplantation, but concerns about the prolonged half-life and potential for hepatotoxicity temper the enthusiasm. As it will likely be several years before similar, shorter acting agents are available, continued study is warranted to discern the appropriate use in human transplantation of this currently available agent.

Original language	English (US)
Pages (from-to)	317-322
Number of pages	6
Journal	Current opinion in organ transplantation
Volume	8
Issue number	4
DOIs	https://doi.org/10.1097/00075200-200312000-00010
State	Published - Jan 1 2003
Externally published	Yes

Keywords

Dosing
Kinetics
Leflunomide
Malononitrilamide
Transplantation

ASJC Scopus subject areas

Immunology and Allergy
Transplantation

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10.1097/00075200-200312000-00010

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title = "Leflunomide: Is there a place for its use in transplantation?",

abstract = "Leflunomide has several properties that make it an excellent candidate for use in transplantation, but concerns about the prolonged half-life and potential for hepatotoxicity temper the enthusiasm. As it will likely be several years before similar, shorter acting agents are available, continued study is warranted to discern the appropriate use in human transplantation of this currently available agent.",

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AU - Brennan, Daniel C.

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AB - Leflunomide has several properties that make it an excellent candidate for use in transplantation, but concerns about the prolonged half-life and potential for hepatotoxicity temper the enthusiasm. As it will likely be several years before similar, shorter acting agents are available, continued study is warranted to discern the appropriate use in human transplantation of this currently available agent.

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KW - Kinetics

KW - Leflunomide

KW - Malononitrilamide

KW - Transplantation

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ER -

Leflunomide: Is there a place for its use in transplantation?

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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