Leading-edge research: PtdIns(3,4,5)P3 and directed migration

Jonathan Franca-Koh, Yoichiro Kamimura, Peter N. Devreotes

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


New studies reveal the dynamic accumulation of phosphatidylinositol (3,4,5) trisphosphate (PtdIns(3,4,5)P3) at the leading edge of primary neutrophils during chemotaxis. They also demonstrate that SHIP1, rather than phosphatase and tensin homologue (PTEN), is responsible for the degradation and localization of this lipid in neutrophils and shed light on the role of PtdIns(3,4,5)P3 in directional sensing.

Original languageEnglish (US)
Pages (from-to)15-17
Number of pages3
JournalNature cell biology
Issue number1
StatePublished - Jan 2007

ASJC Scopus subject areas

  • Cell Biology


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