Lead Induced Histochemical Changes in the Testes of Rats

D. K. Saxena, Bachchu Lal, R. C. Murthy, S. V. Chandra

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


In rats intraperitoneal injection of lead (8 mg/kg as Pb-acetate) over a period of 15 days induced histoenzymic and histological alterations in the testes. Histopathological examination revealed at places degeneration of seminiferous tubules. There were patchy areas showing marked loss in the activity of succinic dehydrogenase and adenosine triphosphatase whereas alkaline phosphatase activity showed only slight inhibition in treated rats. These alterations suggest that in the initial stage of exposure to lead, the disruption of cellular energetics and cation transport in the testicular tissue may be responsible for altering the germinal function of the testis.

Original languageEnglish (US)
Pages (from-to)255-260
Number of pages6
JournalIndustrial Health
Issue number4
StatePublished - 1984
Externally publishedYes


  • Enzymes
  • Histopathology
  • Lead
  • Testes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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