Lead Induced Histochemical Changes in the Testes of Rats

D. K. Saxena; Bachchu Lal; R. C. Murthy; S. V. Chandra

doi:10.2486/indhealth.22.255

Lead Induced Histochemical Changes in the Testes of Rats

D. K. Saxena, Bachchu Lal, R. C. Murthy, S. V. Chandra

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

In rats intraperitoneal injection of lead (8 mg/kg as Pb-acetate) over a period of 15 days induced histoenzymic and histological alterations in the testes. Histopathological examination revealed at places degeneration of seminiferous tubules. There were patchy areas showing marked loss in the activity of succinic dehydrogenase and adenosine triphosphatase whereas alkaline phosphatase activity showed only slight inhibition in treated rats. These alterations suggest that in the initial stage of exposure to lead, the disruption of cellular energetics and cation transport in the testicular tissue may be responsible for altering the germinal function of the testis.

Original language	English (US)
Pages (from-to)	255-260
Number of pages	6
Journal	Industrial Health
Volume	22
Issue number	4
DOIs	https://doi.org/10.2486/indhealth.22.255
State	Published - 1984
Externally published	Yes

Keywords

Enzymes
Histopathology
Lead
Testes

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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10.2486/indhealth.22.255

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abstract = "In rats intraperitoneal injection of lead (8 mg/kg as Pb-acetate) over a period of 15 days induced histoenzymic and histological alterations in the testes. Histopathological examination revealed at places degeneration of seminiferous tubules. There were patchy areas showing marked loss in the activity of succinic dehydrogenase and adenosine triphosphatase whereas alkaline phosphatase activity showed only slight inhibition in treated rats. These alterations suggest that in the initial stage of exposure to lead, the disruption of cellular energetics and cation transport in the testicular tissue may be responsible for altering the germinal function of the testis.",

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author = "Saxena, {D. K.} and Bachchu Lal and Murthy, {R. C.} and Chandra, {S. V.}",

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AU - Saxena, D. K.

AU - Lal, Bachchu

AU - Murthy, R. C.

AU - Chandra, S. V.

PY - 1984

Y1 - 1984

N2 - In rats intraperitoneal injection of lead (8 mg/kg as Pb-acetate) over a period of 15 days induced histoenzymic and histological alterations in the testes. Histopathological examination revealed at places degeneration of seminiferous tubules. There were patchy areas showing marked loss in the activity of succinic dehydrogenase and adenosine triphosphatase whereas alkaline phosphatase activity showed only slight inhibition in treated rats. These alterations suggest that in the initial stage of exposure to lead, the disruption of cellular energetics and cation transport in the testicular tissue may be responsible for altering the germinal function of the testis.

AB - In rats intraperitoneal injection of lead (8 mg/kg as Pb-acetate) over a period of 15 days induced histoenzymic and histological alterations in the testes. Histopathological examination revealed at places degeneration of seminiferous tubules. There were patchy areas showing marked loss in the activity of succinic dehydrogenase and adenosine triphosphatase whereas alkaline phosphatase activity showed only slight inhibition in treated rats. These alterations suggest that in the initial stage of exposure to lead, the disruption of cellular energetics and cation transport in the testicular tissue may be responsible for altering the germinal function of the testis.

KW - Enzymes

KW - Histopathology

KW - Lead

KW - Testes

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Lead Induced Histochemical Changes in the Testes of Rats

Abstract

Keywords

ASJC Scopus subject areas

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