LDL Cholesterol: The Lower the Better

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations


High cholesterol is often a prerequisite for atherosclerotic plaque. Low-density lipoprotein cholesterol (LDL-C) is the focus of the National Cholesterol Education Program Adult Treatment Panel guidelines. LDL-C ranges from 50 to 70 mg/dL in native hunter-gatherers, healthy human neonates, free-living primates, and other wild mammals, who are notably free of atherosclerotic vascular disease. Multiple statin trials and meta-analyses support a treatment target of LDL-C levels less than 70 mg/dL, as this is associated with improved clinical outcomes and atherosclerosis regression. In fact, no threshold has yet been identified below which patients do not benefit from lowering of LDL-C.

Original languageEnglish (US)
Pages (from-to)13-26
Number of pages14
JournalMedical Clinics of North America
Issue number1
StatePublished - Jan 2012


  • Atherosclerosis
  • Coronary risk
  • Low-density lipoprotein cholesterol
  • Statins

ASJC Scopus subject areas

  • Medicine(all)


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