@article{7e95b816b50546df983163531e57ffd6,
title = "Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation",
abstract = "Endogenous neural stem cells (NSCs) in the adult hippocampus are considered to be bi-potent, as they only produce neurons and astrocytes in vivo. In mouse, we found that inactivation of neurofibromin 1 (Nf1), a gene mutated in neurofibromatosis type 1, unlocked a latent oligodendrocyte lineage potential to produce all three lineages from NSCs in vivo. Our results suggest an avenue for promoting stem cell plasticity by targeting barriers of latent lineage potential.",
author = "Sun, {Gerald J.} and Yi Zhou and Shiori Ito and Michael Bonaguidi and Genevieve Stein-O'brien and Kawasaki, {Nicholas K.} and Nikhil Modak and Yuan Zhu and Ming, {Guo Li} and Hongjun Song",
note = "Funding Information: We thank members of the Ming and Song laboratories for discussion, and Y. Cai and L. Liu for technical support. This work was supported by the US National Institutes of Health (NS047344 to H.S., NS080913 to M.A.B., and NS048271 and MH105128 to G.M.), and by a pre-doctoral fellowship from The Children{\textquoteright}s Tumor Foundation to G.J.S. Publisher Copyright: {\textcopyright} 2015 Nature America, Inc.",
year = "2015",
month = nov,
day = "25",
doi = "10.1038/nn.4159",
language = "English (US)",
volume = "18",
pages = "1722--1724",
journal = "Nature neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "12",
}