TY - JOUR
T1 - Latent reservoirs for HIV-1
AU - Blankson, Joel
AU - Persaud, Deborah
AU - Siliciano, Robert F.
PY - 1999/2
Y1 - 1999/2
N2 - Combination therapy for HIV-1 infection can reduce viremia to undetectable levels, suggesting that prolonged treatment might eradicate the infection. However, one potential mechanism for viral persistence involves the establishment of a state of latent infection. Recent studies have directly confirmed that HIV-1 establishes a state of latent infection in resting memory CD4+ T cells in vivo. This reservoir is likely to frustrate current efforts to eradicate the infection with combination therapy.
AB - Combination therapy for HIV-1 infection can reduce viremia to undetectable levels, suggesting that prolonged treatment might eradicate the infection. However, one potential mechanism for viral persistence involves the establishment of a state of latent infection. Recent studies have directly confirmed that HIV-1 establishes a state of latent infection in resting memory CD4+ T cells in vivo. This reservoir is likely to frustrate current efforts to eradicate the infection with combination therapy.
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U2 - 10.1097/00001432-199902000-00002
DO - 10.1097/00001432-199902000-00002
M3 - Review article
C2 - 17035753
AN - SCOPUS:0033012365
SN - 0951-7375
VL - 12
SP - 5
EP - 11
JO - Current opinion in infectious diseases
JF - Current opinion in infectious diseases
IS - 1
ER -