Latency and time-dependent exposure in a case-control study

Lawrence H. Moulton, Monique G. Lê

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Detailed historical data are elicited often from subjects in retrospective studies, yielding time-dependent measures of exposures. Investigation of a hypothesized period of latency can be made by examining disease/exposure relationships in multiple time windows, either along the age or time-before diagnosis axes. We suggest splitting the data into many time intervals and separately fitting regression models tothe available data in each interval. Covariances between estimated coefficients from different intervals are empirically estimated, and used for assessing variability of specified functions of the time-specific coefficients. Alternative methods of interval formation and their consequences are discussed. We apply these methods to a French case-control study of oral contraceptive use and cervical cancer incidence, and compare the results to those of standard analyses.

Original languageEnglish (US)
Pages (from-to)915-923
Number of pages9
JournalJournal of Clinical Epidemiology
Issue number9
StatePublished - 1991
Externally publishedYes


  • Case-control studies
  • Cervical cancer
  • Latent period
  • Logistic regression
  • Longitudinal data analysis
  • Oral contraceptives

ASJC Scopus subject areas

  • Epidemiology


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