Late-life depressive symptoms: Prediction models of change

Carmen García-Peña, Fernando A. Wagner, Sergio Sánchez-Garcí, Claudia Espinel-Bermúdez, Teresa Juárez-Cedillo, Mario Pérez-Zepeda, Victoria Arango-Lopera, Francisco Franco-Marina, Ricardo Ramírez-Aldana, Joseph J. Gallo

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Background: Depression is a well-recognised problem in the elderly. The aim of this study was to determine the factors associated with predictors of change in depressive symptoms, both in subjects with and without baseline significant depressive symptoms. Methods: Longitudinal study of community-dwelling elderly people (> 60 years or older), baseline evaluations, and two additional evaluations were reported. Depressive symptoms were measured using a 30-item geriatric depression scale, and a score of 11 was used as cut-off point for significant depressive symptoms in order to stratify the analyses in two groups: with significant depressive symptoms and without significant depressive symptoms. Sociodemographic data, social support, anxiety, cognition, positive affect, control locus, activities of daily living, recent traumatic life events, physical activity, comorbidities, and quality of life were evaluated. Multi-level generalised estimating equation model was used to assess the impact on the trajectory of depressive symptoms. Results: A number of 7882 subjects were assessed, with 29.42%attrition. At baseline assessment, mean age was 70.96 years, 61.15%were women. Trajectories of depressive symptoms had a decreasing trend. Stronger associations in those with significant depressive symptoms, were social support (OR.971, p < .001), chronic pain (OR 2.277, p < .001) and higher locus of control (OR.581, p < .001). In contrast for those without baseline significant depressive symptoms anxiety and a higher locus of control were the strongest associations. Conclusions: New insights into late-life depression are provided, with special emphasis in differentiated factors influencing the trajectory when stratifying regarding basal status of significant depressive symptoms. Limitations: The study has not included clinical evaluations and nutritional assessments.

Original languageEnglish (US)
Pages (from-to)886-894
Number of pages9
JournalJournal of Affective Disorders
Issue number3
StatePublished - Sep 25 2013


  • Depression trajectories
  • Depressive symptoms
  • Geriatric depression scale
  • Geriatric syndromes
  • Late-life depression

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health


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