LASIK interface keratitis: Epidemiology, diagnosis and care

David C. Gritz

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Purpose of review: Diffuse lamellar keratitis (DLK) is one of the more common interface complications occurs after laser in-situ keratomileusis (LASIK). The diagnosis can sometimes be challenging, as the differential diagnosis includes infectious keratitis, which requires a completely different treatment compared to DLK. This review assesses our current knowledge of the epidemiology, diagnosis and treatment of DLK. Recent findings: DLK occurs during the immediate postoperative period, but there are also late-onset cases. Early cases can occur in outbreaks, related to exogenous factors. Late-onset cases are most often related to inciting factors. Over time, case reports and series have reported DLK onset occurring further after surgery. It is probable that additional inciting factors will also be reported over time. Visual outcomes following DLK tend to be good when the condition is diagnosed properly and treated with intensive topical or systemic steroids, possibly combined with interface irrigation. Summary: DLK is a well recognized and well described complication occurring after LASIK. Associated inciting and risk factors and treatment algorithms have been described, but additional questions remain. Our knowledge and our patients will benefit from further research and development of evidence-based treatments.

Original languageEnglish (US)
Pages (from-to)251-255
Number of pages5
JournalCurrent opinion in ophthalmology
Issue number4
StatePublished - Jul 1 2011


  • diffuse lamellar keratitis
  • epidemiology
  • inflammation
  • laser in-situ keratomileusis

ASJC Scopus subject areas

  • Ophthalmology


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