TY - JOUR
T1 - Laser speckle imaging to improve clinical outcomes for patients with trigeminal neuralgia undergoing radiofrequency thermocoagulation
AU - Ringkamp, Matthias
AU - Wooten, Matthew
AU - Carson, Benjamin S.
AU - Lim, Michael
AU - Hartke, Timothy
AU - Guarnieri, Michael
N1 - Publisher Copyright:
©AANS, 2016
PY - 2016
Y1 - 2016
N2 - OBJECTIVE: Percutaneous treatments for trigeminal neuralgia are safe, simple, and effective for achieving good pain control. Procedural risks could be minimized by using noninvasive imaging techniques to improve the placement of the radiofrequency thermocoagulation probe into the trigeminal ganglion. Positioning of a probe is crucial to maximize pain relief and to minimize unwanted side effects, such as denervation in unaffected areas. This investigation examined the use of laser speckle imaging during probe placement in an animal model. METHODS: This preclinical safety study used nonhuman primates, Macaca nemestrina (pigtail monkeys), to examine whether real-time imaging of blood flow in the face during the positioning of a coagulation probe could monitor the location and guide the positioning of the probe within the trigeminal ganglion. RESULTS: Data from 6 experiments in 3 pigtail monkeys support the hypothesis that laser imaging is safe and improves the accuracy of probe placement. CONCLUSIONS: Noninvasive laser speckle imaging can be performed safely in nonhuman primates. Because improved probe placement may reduce morbidity associated with percutaneous rhizotomies, efficacy trials of laser speckle imaging should be conducted in humans.
AB - OBJECTIVE: Percutaneous treatments for trigeminal neuralgia are safe, simple, and effective for achieving good pain control. Procedural risks could be minimized by using noninvasive imaging techniques to improve the placement of the radiofrequency thermocoagulation probe into the trigeminal ganglion. Positioning of a probe is crucial to maximize pain relief and to minimize unwanted side effects, such as denervation in unaffected areas. This investigation examined the use of laser speckle imaging during probe placement in an animal model. METHODS: This preclinical safety study used nonhuman primates, Macaca nemestrina (pigtail monkeys), to examine whether real-time imaging of blood flow in the face during the positioning of a coagulation probe could monitor the location and guide the positioning of the probe within the trigeminal ganglion. RESULTS: Data from 6 experiments in 3 pigtail monkeys support the hypothesis that laser imaging is safe and improves the accuracy of probe placement. CONCLUSIONS: Noninvasive laser speckle imaging can be performed safely in nonhuman primates. Because improved probe placement may reduce morbidity associated with percutaneous rhizotomies, efficacy trials of laser speckle imaging should be conducted in humans.
KW - Functional neurosurgery
KW - Laser speckle imaging
KW - Multiple sclerosis
KW - Pain
KW - Preclinical safety study
KW - Radiofrequency thermocoagulation
KW - Trigeminal neuralgia
UR - http://www.scopus.com/inward/record.url?scp=84976598223&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84976598223&partnerID=8YFLogxK
U2 - 10.3171/2015.1.JNS14408
DO - 10.3171/2015.1.JNS14408
M3 - Article
C2 - 26274997
AN - SCOPUS:84976598223
SN - 0022-3085
VL - 124
SP - 422
EP - 428
JO - Journal of neurosurgery
JF - Journal of neurosurgery
IS - 2
ER -