Abstract
Poly(sebacic anhydride) (PSA) is biocompatible and degradable in basic media. We micronized this water-insoluble polymer into stable polymeric nanoparticles via a microphase inversion. Such PSA nanoparticles degraded much faster than bulk PSA. The influence of the surfactant, temperature, and pH on the degradation of the PSA nanoparticles was investigated by a combination of static and dynamic laser light scattering. Under each condition, the degradation rate was nearly constant up to a 75% weight loss; that is, the degradation was close to zero-order. The degradation rate increased with the pH and temperature. Biomedical applications of such PSA nanoparticles are suggested.
Original language | English (US) |
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Pages (from-to) | 703-708 |
Number of pages | 6 |
Journal | Journal of Polymer Science, Part B: Polymer Physics |
Volume | 39 |
Issue number | 6 |
DOIs | |
State | Published - Mar 15 2001 |
Externally published | Yes |
ASJC Scopus subject areas
- Condensed Matter Physics
- Physical and Theoretical Chemistry
- Polymers and Plastics
- Materials Chemistry