Abstract
Fourteen BALB/c mice were divided into two groups. One group served as the control and the second group was injected with a squamous cell carcinoma cell line to the tongue. After tumor development (1-4 weeks), mice were injected with a FITC conjugated CD3 marker to their tongues. Immediately after the marker injection, the clearance of the marker was measured using a laser spectroscopy system. The markers were excited by an argon laser at 488 nm and the fluorescence signal was measured as a function of time. A biopsy was taken from every mouse after the procedure and the excised tissue was histologically evaluated. Analysis of clearance times revealed a second order exponential decay for both groups with a slower pace of signal clearance for the sick mice.
Original language | English (US) |
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Pages (from-to) | 14-19 |
Number of pages | 6 |
Journal | Journal of biomedical optics |
Volume | 7 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2002 |
Externally published | Yes |
Keywords
- Fluorescence
- Lasers
- Tissues
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Atomic and Molecular Physics, and Optics
- Biomedical Engineering