Larvicidal, antimycobacterial and antifungal compounds from the bark of the peruvian plant Swartzia polyphylla DC

Rosario Rojas; Betty Bustamante; Palmira Ventosilla; Irma Fernádez; Luz Caviedes; Robert Henry Gilman; Olga Lock; Gerald Bruce Hammond

doi:10.1248/cpb.54

Larvicidal, antimycobacterial and antifungal compounds from the bark of the peruvian plant Swartzia polyphylla DC

Rosario Rojas, Betty Bustamante, Palmira Ventosilla, Irma Fernádez, Luz Caviedes, Robert Henry Gilman, Olga Lock, Gerald Bruce Hammond

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The 95% ethanol extract of the bark of Swartzia polyphylla DC (Fabaceae) possesses important larvicidal, antimycobacterial and antifungal activity in vitro. Bioassay-guided studies performed on the crude ethanol extract afforded T-cadinol as the larvicidal and anti-Mycobacterium tuberculosis principle, while the antifungal activity of the extract is due to the presence of the flavonoids biochanin A and dihydrobiochanin A.

Original language	English (US)
Pages (from-to)	278-279
Number of pages	2
Journal	Chemical and Pharmaceutical Bulletin
Volume	54
Issue number	2
DOIs	https://doi.org/10.1248/cpb.54
State	Published - Feb 1 2006

Keywords

Antifungal
Antimycobacterial
Biochanin A
Dihydrobiochanin A
Larvicidal
Swartzia polyphylla

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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abstract = "The 95% ethanol extract of the bark of Swartzia polyphylla DC (Fabaceae) possesses important larvicidal, antimycobacterial and antifungal activity in vitro. Bioassay-guided studies performed on the crude ethanol extract afforded T-cadinol as the larvicidal and anti-Mycobacterium tuberculosis principle, while the antifungal activity of the extract is due to the presence of the flavonoids biochanin A and dihydrobiochanin A.",

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AU - Rojas, Rosario

AU - Bustamante, Betty

AU - Ventosilla, Palmira

AU - Fernádez, Irma

AU - Caviedes, Luz

AU - Gilman, Robert Henry

AU - Lock, Olga

AU - Hammond, Gerald Bruce

PY - 2006/2/1

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N2 - The 95% ethanol extract of the bark of Swartzia polyphylla DC (Fabaceae) possesses important larvicidal, antimycobacterial and antifungal activity in vitro. Bioassay-guided studies performed on the crude ethanol extract afforded T-cadinol as the larvicidal and anti-Mycobacterium tuberculosis principle, while the antifungal activity of the extract is due to the presence of the flavonoids biochanin A and dihydrobiochanin A.

AB - The 95% ethanol extract of the bark of Swartzia polyphylla DC (Fabaceae) possesses important larvicidal, antimycobacterial and antifungal activity in vitro. Bioassay-guided studies performed on the crude ethanol extract afforded T-cadinol as the larvicidal and anti-Mycobacterium tuberculosis principle, while the antifungal activity of the extract is due to the presence of the flavonoids biochanin A and dihydrobiochanin A.

KW - Antifungal

KW - Antimycobacterial

KW - Biochanin A

KW - Dihydrobiochanin A

KW - Larvicidal

KW - Swartzia polyphylla

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ER -

Larvicidal, antimycobacterial and antifungal compounds from the bark of the peruvian plant Swartzia polyphylla DC

Abstract

Keywords

ASJC Scopus subject areas

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