Large-Cell Neuroendocrine Carcinoma of the Lung: An Aggressive Neuroendocrine Lung Cancer

Felix G. Fernandez, Richard J. Battafarano

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Large cell neuroendocrine carcinoma (LCNEC) is part of the neuroendocrine spectrum of pulmonary tumors. This increasingly recognized tumor has been reported to have 5-year actuarial survival rates following resection that are worse than those described for other variants of non-small cell lung cancer (NSCLC). Therefore, debate has emerged regarding whether the tumors should be classified and treated as NSCLC or small-cell lung cancer. This article reviews the tumor characterization, biology, presentation and diagnosis, surgical therapy, results of therapy, and long term prognosis of patients with LCNEC.

Original languageEnglish (US)
Pages (from-to)206-210
Number of pages5
JournalSeminars in thoracic and cardiovascular surgery
Issue number3
StatePublished - 2006
Externally publishedYes


  • large cell neuroendocrine carcinoma
  • neuroendocrine spectrum
  • non-small cell lung cancer
  • pulmonary tumors

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Large-Cell Neuroendocrine Carcinoma of the Lung: An Aggressive Neuroendocrine Lung Cancer'. Together they form a unique fingerprint.

Cite this